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  1. Article

    Open Access

    Role of hepcidin in oxidative stress and cell death of cultured mouse renal collecting duct cells: protection against iron and sensitization to cadmium

    The liver hormone hepcidin regulates systemic iron homeostasis. Hepcidin is also expressed by the kidney, but exclusively in distal nephron segments. Several studies suggest hepcidin protects against kidney da...

    Stephanie Probst, Johannes Fels, Bettina Scharner… in Archives of Toxicology (2021)

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  2. Article

    Open Access

    A role for divalent metal transporter (DMT1) in mitochondrial uptake of iron and manganese

    Much of iron and manganese metabolism occurs in mitochondria. Uptake of redox-active iron must be tightly controlled, but little is known about how metal ions enter mitochondria. Recently, we established that ...

    Natascha A. Wolff , Michael D. Garrick, Lin Zhao, Laura M. Garrick… in Scientific Reports (2018)

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  3. Article

    Open Access

    Cadmium induces Wnt signaling to upregulate proliferation and survival genes in sub-confluent kidney proximal tubule cells

    The class 1 carcinogen cadmium (Cd2+) disrupts the E-cadherin/β-catenin complex of epithelial adherens junctions (AJs) and causes renal cancer. Deregulation of E-cadherin adhesion and changes in Wnt/β-catenin sig...

    Prabir K Chakraborty, Wing-Kee Lee, Malte Molitor, Natascha A Wolff… in Molecular Cancer (2010)

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  4. No Access

    Article

    Cadmium induces nuclear translocation of β-catenin and increases expression of c-myc and Abcb1a in kidney proximal tubule cells

    Cadmium (Cd2+) induces renal proximal tubular (PT) damage, including disruption of the E-cadherin/β-catenin complex of adherens junctions (AJs) and apoptosis. Yet, chronic Cd2+ exposure causes malignant transform...

    Frank Thévenod, Natascha A. Wolff, Ulrich Bork, Wing-Kee Lee… in BioMetals (2007)

  5. No Access

    Article

    Molecular characterization of the renal organic anion transporter 1

    Organic anions of diverse chemical structures are secreted in renal proximal tubules. The first step in secretion, uptake of organic anions across the basolateral membrane of tubule cells, is mediated for the ...

    Gerhard Burckhardt, Natascha A. Wolff, Andrew Bahn in Cell Biochemistry and Biophysics (2002)

  6. No Access

    Article

    Voltage-driven p-aminohippurate, chloride, and urate transport in porcine renal brush-border membrane vesicles

    p-Aminohippurate (PAH) and urate are secreted into the proximal tubule lumen across the brush-border membrane. Here we used brush-border membrane vesicles from pig kidney to study PAH and urate ...

    Wolfgang Krick, Natascha A. Wolff, Gerhard Burckhardt in Pflügers Archiv (2000)

  7. No Access

    Article

    Functional expression of renal organic anion transport in Xenopus laevis oocytes

    Secretion of organic anions by the kidney plays a critical role in the elimination of toxic agents from the body. Recent findings in isolated membranes and intact tissue have demonstrated the participation of ...

    Natascha A. Wolff, Richard M. Philpot… in Molecular and Cellular Biochemistry (1992)

  8. No Access

    Article

    Renal handling of taurine,l-alanine,l-glutamate andd-glucose inOpsanus tau: studies on isolated brush border membrane vesicles

    Renal brush border membrane vesicles (bbmv) from the aglomerular toadfish (Opsanus tau), isolated by differential precipitation, were tested for their ability to actively translocate (i) taurine, known to be secr...

    Natascha A. Wolff, Rolf Kinne, Bernd Elger… in Journal of Comparative Physiology B (1987)