61 Result(s)
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Alberto Mantovani
Immunology
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Article
Open AccessLegacy of the discovery of the T-cell receptor: 40 years of sha** basic immunology and translational work to develop novel therapies
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Article
Open AccessAutoantibodies against chemokines post-SARS-CoV-2 infection correlate with disease course
Infection with severe acute respiratory syndrome coronavirus 2 associates with diverse symptoms, which can persist for months. While antiviral antibodies are protective, those targeting interferons and other i...
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Reply to: Hultström et al., Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19. Mannose-binding lectin genetics in COVID-19
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Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules
The humoral arm of innate immunity includes diverse molecules with antibody-like functions, some of which serve as disease severity biomarkers in coronavirus disease 2019 (COVID-19). The present study was desi...
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Article
Tumor-associated myeloid cells: diversity and therapeutic targeting
Myeloid cells in tumor tissues constitute a dynamic immune population characterized by a non-uniform phenotype and diverse functional activities. Both tumor-associated macrophages (TAMs), which are more abunda...
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Author Correction: A guiding map for inflammation
A Correction to this paper has been published: https://doi.org/10.1038/ni.3790
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Chapter
Adoptive T-Cell Therapy: Optimizing Chemokine Receptor-Mediated Homing of T-Cells in Cancer Immunotherapy
Immunotherapy based on adoptive T-cell transfer provides a promising form of cancer therapy, but often fails to induce long-lasting responses in the great majority of patients. During the past few decades, sev...
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Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19
Long pentraxin 3 (PTX3) is an essential component of humoral innate immunity, involved in resistance to selected pathogens and in the regulation of inflammation1–3. The present study was designed to assess the pr...
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The other side of the innate immune system: humoral arms favoring cancer
Cancer cells take advantage of NETosis to escape host immune surveillance and mediate metastasis. The pharmacological targeting of NETosis may prove beneficial in maximizing the response to cancer immunotherapy.
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Chapter
Tumor-Associated Myeloid Cells in Cancer Progression
The tumor microenvironment plays a pivotal role in orchestrating tumor initiation, progression, and spreading, as well as response to therapy. Myeloid immune cells infiltrating tumors are integral component of...
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‘Stealth’ corporate innovation: an emerging threat for therapeutic drug development
Therapeutic innovations of potentially great clinical impact should embrace the overarching values of research accountability, data transparency and validation through the scientific peer-review process.
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Author Correction: ‘Stealth’ corporate innovation: an emerging threat for therapeutic drug development
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessThe great debate at “Immunotherapy Bridge 2018”, Naples, November 29th, 2018
As part of the 2018 Immunotherapy Bridge congress (November 28–29, Naples, Italy), the Great Debate session featured counterpoint views from leading experts on four topical clinical issues in immunotherapy tod...
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The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell–mediated resistance to metastasis
The plasma membrane tetraspan molecule MS4A4A is selectively expressed by macrophage-lineage cells, but its function is unknown. Here we report that MS4A4A was restricted to murine and human mononuclear phagoc...
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Microenvironment and Immunology of the Human Pleural Malignant Mesothelioma
Human malignant pleural mesothelioma (MPM) is strongly related to pre-existing and long-lasting conditions of chronic inflammation and tissue injury, caused by the inhalation of airborne asbestos fibers. The l...
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Alessandro Moretta 1953–2018
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Complement in cancer: untangling an intricate relationship
Complement potentiates various forms of cancer therapy, including antibody-mediated cytotoxicity, vaccines and radiotherapy.
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A guiding map for inflammation
Netea and colleagues provide a general guide to the cellular and humoral contributors to inflammation as well as the pathways that characterize inflammation in specific organs and tissues.
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Atypical matters in myeloid differentiation
Chemokines are important components of the hematopoietic niche. The atypical chemokine receptor 1 (ACKR1), expressed on erythrocyte precursors, regulates myeloid differentiation.
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Reflections on immunological nomenclature: in praise of imperfection
