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  1. No Access

    Article

    Immune checkpoints in cardiac physiology and pathology: therapeutic targets for heart failure

    Immune checkpoint molecules are physiological regulators of the adaptive immune response. Immune checkpoint inhibitors (ICIs), such as monoclonal antibodies targeting programmed cell death protein 1 or cytotox...

    Tamás G. Gergely, Zsófia D. Drobni, Marinos Kallikourdis… in Nature Reviews Cardiology (2024)

  2. No Access

    Article

    Immunometabolic mechanisms of heart failure with preserved ejection fraction

    Heart failure with preserved ejection fraction (HFpEF) is increasing in prevalence worldwide, already accounting for at least half of all cases of heart failure. As most patients with HFpEF are obese with meta...

    Gabriele G. Schiattarella, Pilar Alcaide… in Nature Cardiovascular Research (2022)

  3. No Access

    Chapter

    Adoptive T-Cell Therapy: Optimizing Chemokine Receptor-Mediated Homing of T-Cells in Cancer Immunotherapy

    Immunotherapy based on adoptive T-cell transfer provides a promising form of cancer therapy, but often fails to induce long-lasting responses in the great majority of patients. During the past few decades, sev...

    Imran Siddiqui, Debora Vignali, Marinos Kallikourdis… in Cancer Immunology (2021)

  4. No Access

    Article

    Risk of hospitalization for heart failure in rheumatoid arthritis patients treated with etanercept and abatacept

    To estimate biologic influence on heart failure (HF) risk in rheumatoid arthritis. Retrospective cohort (RECORD Study of Italian Society for Rheumatology) study on administrative healthcare databases. We ident...

    Elena Generali, Greta Carrara, Marinos Kallikourdis… in Rheumatology International (2019)

  5. No Access

    Chapter

    The WHIM Syndrome

    The WHIM syndrome is a rare immunodeficiency characterized by Warts, Hypogammaglobulinemia, recurrent respiratory bacterial Infections, and Myelokathexis. Early studies identified that neutrophils in WHIM pati...

    Giuliana Roselli, Marinos Kallikourdis… in Humoral Primary Immunodeficiencies (2019)

  6. No Access

    Article

    T cell responses to tumor: how dominant assumptions on immune activity led to a neglect of pathological functions, and how evolutionary considerations can help identify testable hypotheses for improving immunotherapy

    Cancer immunotherapy is based on the premise that activated, pro-inflammatory T cell responses to tumor will mostly combat tumor growth. Nowadays accepted as largely valid, this hypothesis has been formed as a...

    Marinos Kallikourdis in Cancer Immunology, Immunotherapy (2018)

  7. Article

    Open Access

    T cell costimulation blockade blunts pressure overload-induced heart failure

    Heart failure (HF) is a leading cause of mortality. Inflammation is implicated in HF, yet clinical trials targeting pro-inflammatory cytokines in HF were unsuccessful, possibly due to redundant functions of in...

    Marinos Kallikourdis, Elisa Martini, Pierluigi Carullo… in Nature Communications (2017)

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  8. No Access

    Chapter

    Chemokines and T Cell Trafficking into Tumors: Strategies to Enhance Recruitment of T Cells into Tumors

    Chemokines are small proteins used by the cells of the immune system in order to orchestrate their movement in the body during physiological and pathological conditions. Yet they are also expressed in tumors a...

    Stefano Garetto, Claudia Sardi, Diego Morone… in Defects in T Cell Trafficking and Resistan… (2016)

  9. No Access

    Article

    Tolerance, suppression and the fetal allograft

    In solid organ transplantation the recipient immune system recognises foreign alloantigens expressed by the graft. This results in an immune attack of the transplanted organ leading to rejection, which can be ...

    Varuna R. Aluvihare, Marinos Kallikourdis… in Journal of Molecular Medicine (2005)

  10. No Access

    Article

    Regulatory T cells mediate maternal tolerance to the fetus

    Pregnancy constitutes a major challenge to the maternal immune system, as it has to tolerate the persistence of paternal alloantigen. Although localized mechanisms contribute to fetal evasion from immune attac...

    Varuna R Aluvihare, Marinos Kallikourdis, Alexander G Betz in Nature Immunology (2004)

  11. No Access

    Article

    B cells and professional APCs recruit regulatory T cells via CCL4

    Using gene expression profiling, we show here that activation of B cells and professional antigen-presenting cells (APCs) induces the expression of common chemokines. Among these, CCL4 was the most potent chem...

    Richard S. Bystry, Varuna Aluvihare, Katie A. Welch… in Nature Immunology (2001)