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Open AccessFeasibility of Indirect Treatment Comparisons Between Niraparib Plus Abiraterone Acetate and Other First-Line Poly ADP-Ribose Polymerase Inhibitor Treatment Regimens for Patients with BRCA1/2 Mutation-Positive Metastatic Castration-Resistant Prostate Cancer
Poly(ADP-ribose) polymerase inhibitors (PARPi) are a novel option to treat patients with metastatic castration-resistant prostate cancer (mCRPC). Niraparib plus abiraterone acetate and prednisone (AAP) is ind...
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Article
Sequenztherapie des fortgeschrittenen Urothelkarzinoms der Harnblase nach vorheriger perioperativer Systembehandlung
Leitlinien können eindeutige Therapieempfehlungen für definierte Patientengruppen immer nur dann aussprechen, wenn qualitativ gute und aussagekräftige Studiendaten für diese vorliegen. Klinische Studien zur Th...
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Treatable Traits in Systemic Sclerosis
Systemic sclerosis (SSc) is a chronic systemic disease within the spectrum of connective tissue diseases, specifically characterized by vascular abnormalities and inflammatory and fibrotic involvement of the s...
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Advanced Imaging Supports the Mechanistic Role of Autoimmunity and Plaque Rupture in COVID-19 Heart Involvement
The cardiovascular system is frequently affected by coronavirus disease-19 (COVID-19), particularly in hospitalized cases, and these manifestations are associated with a worse prognosis. Most commonly, heart i...
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Systemic syndromes of rheumatological interest with onset after COVID-19 vaccine administration: a report of 30 cases
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Open AccessMicroRNAs in Axial Spondylarthritis: an Overview of the Recent Progresses in the Field with a Focus on Ankylosing Spondylitis and Psoriatic Arthritis
To highlight the recent discoveries and lines of evidence on the role of microRNAs in ankylosing spondylitis (AS) and psoriatic arthritis (PsA), focusing on their expression profiling and mechanisms of action.
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Open AccessExplorative analysis of a score predicting the therapy response of patients with metastatic, castration resistant prostate cancer undergoing radioligand therapy with 177Lu-labeled prostate-specific membrane antigen
Up to 60% of patients with metastatic, castration-resistant prostate cancer (mCRPC) treated with 177Lu prostate-specific membrane antigen (PSMA) radioligand therapy (RLT) achieves a partial biochemical response w...
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Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19
Long pentraxin 3 (PTX3) is an essential component of humoral innate immunity, involved in resistance to selected pathogens and in the regulation of inflammation1–3. The present study was designed to assess the pr...
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The other side of the innate immune system: humoral arms favoring cancer
Cancer cells take advantage of NETosis to escape host immune surveillance and mediate metastasis. The pharmacological targeting of NETosis may prove beneficial in maximizing the response to cancer immunotherapy.
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Open AccessConcomitant Pyoderma Gangrenosum-like and Amicrobial Pustulosis of the Folds: a Case Report
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Aktuelle medikamentöse Therapiekonzepte des metastasierten Prostatakarzinoms
Seit der Einführung der Androgendeprivationstherapie (ADT) vor mehr als 70 Jahren durch chirurgische Kastration hat sich die medikamentöse Therapie des metastasierten Prostatakarzinoms (PCa) erheblich diversif...
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Neue Systemtherapien und Studien beim Prostatakarzinom
Die Systemtherapie beim Prostatakarzinom war lange darauf limitiert, die Testosteronwirkung auf die Tumorzellen zu hemmen. Nun könnten Therapie- und Therapiesequenzauswahl komplexer — das inkurable metastasier...
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Pembrolizumab for Previously Treated Advanced or Metastatic Urothelial Cancer: An Evidence Review Group Perspective of a NICE Single Technology Appraisal
Pembrolizumab is an intravenously administered monoclonal antibody licensed for locally advanced or metastatic urothelial carcinoma after platinum-containing chemotherapy. This summary presents the perspective...
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Radical treatment of muscle-invasive bladder cancer—are options equal?
To compare the modalities used to treat muscle-invasive bladder cancer (MIBC) and assess response to fractionated neoadjuvant chemotherapy.
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Article
The elegance of a macrophage
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Open AccessPersonalized medicine in rheumatology: the paradigm of serum autoantibodies
The sequencing of the human genome is now well recognized as the starting point of personalized medicine. Nonetheless, everyone is unique and can develop different phenotypes of the same disease, despite ident...
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Myositis-specific autoantibodies and their association with malignancy in Italian patients with polymyositis and dermatomyositis
This study aims to characterize myositis-specific antibodies in a well-defined cohort of patients with idiopathic inflammatory myopathy and to determine their association with cancer. Sera from 40 patients wit...
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The Immune Response and the Pathogenesis of Idiopathic Inflammatory Myositis: a Critical Review
The pathogenesis of idiopathic inflammatory myositis (IIMs, including polymyositis and dermatomyositis) remains largely enigmatic, despite advances in the study of the role played by innate immunity, adaptive ...
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Open Access31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one
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Open AccessNailfold videocapillaroscopy and serum VEGF levels in scleroderma are associated with internal organ involvement
Nailfold videocapillaroscopy (NVC) identifies the microvascular hallmarks of systemic sclerosis (SSc) and vascular endothelial growth factor (VEGF) and may play a pivotal role in the associated vasculopathy. ...
