-
Article
Open AccessMacrophages and cancer stem cells: a malevolent alliance
Myeloid cells infiltrating tumors are gaining ever growing attention in the last years because their pro-tumor and immunosuppressive functions are relevant for disease progression and therapeutic responses. Th...
-
Chapter
Trabectedin, a Drug Acting on Both Cancer Cells and the Tumor Microenvironment
In the last decades the cancer cell-centric paradigm has changed to consider the tumor micro-environment (TME) as a whole. Immune cells present in the TME establish a complex relationship with cancer cells and...
-
Article
Open AccessSenescent thyrocytes and thyroid tumor cells induce M2-like macrophage polarization of human monocytes via a PGE2-dependent mechanism
Thyroid carcinoma includes several variants characterized by different biological and clinical features: from indolent microcarcinoma to undifferentiated and aggressive anaplastic carcinoma. Inflammation plays...
-
Chapter
Microenvironment and Immunology of the Human Pleural Malignant Mesothelioma
Human malignant pleural mesothelioma (MPM) is strongly related to pre-existing and long-lasting conditions of chronic inflammation and tissue injury, caused by the inhalation of airborne asbestos fibers. The l...
-
Article
Open AccessCells with stemness features are generated from in vitro transformed human fibroblasts
Cancer stem cells (CSCs) have been involved in the maintenance, progression and relapse of several tumors, but their origin is still elusive. Here, in vitro transformed human fibroblasts (cen3tel cells) and the t...
-
Article
Open AccessLurbinectedin reduces tumour-associated macrophages and the inflammatory tumour microenvironment in preclinical models
Lurbinectedin is a novel anticancer agent currently undergoing late-stage (Phase II /III) clinical evaluation in platinum-resistant ovarian, BRCA1/2-mutated breast and small-cell lung cancer. Lurbinectedin is ...
-
Article
Tumor-associated macrophages and anti-tumor therapies: complex links
Myeloid cells infiltrating the tumor microenvironment, especially tumor-associated macrophages (TAMs), are essential providers of cancer-related inflammation, a condition known to accelerate tumor progression ...
-
Article
Modulation of the myeloid compartment of the immune system by angiogenic- and kinase inhibitor-targeted anti-cancer therapies
Targeted therapies were rationally designed to inhibit molecular pathways in tumor cells critically involved in growth and survival; however, many drugs used in targeted therapies may affect the immune system...
