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Open AccessA model for malaria elimination based on learnings from the Malaria Elimination Demonstration Project, Mandla district, Madhya Pradesh
Malaria Elimination Demonstration Project (MEDP) was started as a Public-Private-Partnership between the Indian Council of Medical Research through National Institute of Research in Tribal Health, Govt. of Mad...
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The malaria parasite Plasmodium vivax exhibits greater genetic diversity than Plasmodium falciparum
Jane Carlton and colleagues report the genome sequencing, de novo assembly and annotation of four Plasmodium vivax reference strains from diverse geographic locations. Their cross-species comparisons show that P....
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Open AccessEffectiveness and durability of Interceptor® long-lasting insecticidal nets in a malaria endemic area of central India
In the present study, Interceptor®, long-lasting polyester net, 75 denier and bursting strength of minimum 250 kPa coated with alpha-cypermethrin @ 200 mg/m2 was evaluated for its efficacy in reducing the mosquit...
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Open AccessArtesunate-amodiaquine fixed dose combination for the treatment of Plasmodium falciparum malaria in India
Artemisinin-based combination therapy (ACT) has been recommended for the treatment of falciparum malaria by the World Health Organization. Though India has already switched to ACT for treating falciparum malaria,...
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Open AccessMutant pfcrt "SVMNT" haplotype and wild type pfmdr1 "N86" are endemic in Plasmodium vivax dominated areas of India under high chloroquine exposure
Chloroquine resistance (CQR) phenotype in Plasmodium falciparum is associated with mutations in pfcrt and pfmdr-1 genes. Mutations at amino acid position 72-76 of pfcrt gene, here defined as pfcrt haplotype are a...
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Open AccessPlasmodium vivax lineages: geographical distribution, tandem repeat polymorphism, and phylogenetic relationship
Multi-drug resistance and severe/complicated cases are the emerging phenotypes of vivax malaria, which may deteriorate current anti-malarial control measures. The emergence of these phenotypes could be associa...
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Open AccessComparative efficacy of two poeciliid fish in indoor cement tanks against chikungunya vector Aedes aegyptiin villages in Karnataka, India
In 2006, severe outbreaks of Aedes aegypti-transmitted chikungunya occurred in villages in Karnataka, South India. We evaluated the effectiveness of combined information, education and communication (IEC) campaig...
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Open AccessStatus of pesticide management in the practice of vector control: a global survey in countries at risk of malaria or other major vector-borne diseases
It is critical that vector control pesticides are used for their acceptable purpose without causing adverse effects on health and the environment. This paper provides a global overview of the current status of...
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Malaria vector control: from past to future
Malaria is one of the most common vector-borne diseases widespread in the tropical and subtropical regions. Despite considerable success of malaria control programs in the past, malaria still continues as a ma...
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Open AccessChlorfenapyr: a new insecticide with novel mode of action can control pyrethroid resistant malaria vectors
Malaria vectors have acquired widespread resistance to many of the currently used insecticides, including synthetic pyrethroids. Hence, there is an urgent need to develop alternative insecticides for effective...
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Open AccessPersistent transmission of malaria in Garo hills of Meghalaya bordering Bangladesh, north-east India
Malaria is endemic in Garo hills of Meghalaya, and death cases are reported annually. Plasmodium falciparum is the major parasite, and is solely responsible for each malaria-attributable death case. Garo hills ar...
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Open AccessAvailability and utilization of malaria prevention strategies in pregnancy in eastern India
Malaria in pregnancy in India, as elsewhere, is responsible for maternal anemia and adverse pregnancy outcomes such as low birth weight and preterm birth.
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Open AccessReduced susceptibility to selected synthetic pyrethroids in urban malaria vector Anopheles stephensi: a case study in Mangalore city, South India
Synthetic pyrethroids are potent insecticides most commonly used in the vector control programme. These are applied for indoor residual sprays, space sprays and in impregnated bed nets. Resistance reduces the ...
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Vivax malaria presenting with cerebral malaria and convulsions
A patient was admitted with fever, vomiting, restlessness and convulsions. He was febrile and unconscious. Laboratory tests showed a low platelet count and ruled out enteric fever and dengue. His peripheral bl...
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Climate change and threat of vector-borne diseases in India: are we prepared?
It is unequivocal that climate change is happening and is likely to expand the geographical distribution of several vector-borne diseases, including malaria and dengue etc. to higher altitudes and latitudes. I...
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Evolutionary genetic insights into Plasmodium falciparum functional genes
Complex and rapidly evolving behavior of the human malaria parasite Plasmodium falciparum have always been mysterious to the evolutionary biologists, as the parasite is the most virulent and now becoming the most...
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Open AccessBurden of malaria in pregnancy in Jharkhand State, India
Past studies in India included only symptomatic pregnant women and thus may have overestimated the proportion of women with malaria. Given the large population at risk, a cross sectional study was conducted in...
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Open AccessPCR-based methods for the detection of L1014 kdr mutation in Anopheles culicifacies sensu lato
Anopheles culicifacies s.l., a major malaria vector in India, has developed widespread resistance to DDT and is becoming resistant to pyrethroids–the only insecticide class recommended for the impregnation of bed...
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Open AccessLarvicidal activity of neem oil (Azadirachta indica) formulation against mosquitoes
Mosquitoes transmit serious human diseases, causing millions of deaths every year. Use of synthetic insecticides to control vector mosquitoes has caused physiological resistance and adverse environmental effec...
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Open AccessTherapeutic efficacy of artemether-lumefantrine in uncomplicated falciparum malaria in India
Artemisinin-based combination therapy (ACT) is the treatment of choice for uncomplicated falciparum malaria. Artemether-lumefantrine (AL), a fixed dose co-formulation, has recently been approved for marketing ...
