-
Article
Open AccessBeneficial effects of premeal almond load on glucose profile on oral glucose tolerance and continuous glucose monitoring: randomized crossover trials in Asian Indians with prediabetes
Rapid conversion from prediabetes to diabetes and frequent postprandial hyperglycemia (PPHG) is seen in Asian Indians. These should be the target of dietary strategies.
-
Article
Open AccessGenetic interaction between RLM1 and F-box motif encoding gene SAF1 contributes to stress response in Saccharomyces cerevisiae
Stress response is mediated by the transcription of stress-responsive genes. The F-box motif protein Saf1p is involved in SCF-E3 ligase mediated degradation of the adenine deaminase, Aah1p upon nutrient stress...
-
Article
The influence of polymorphisms of fat mass and obesity (FTO, rs9939609) and vitamin D receptor (VDR, BsmI, TaqI, ApaI, FokI) genes on weight loss by diet and exercise interventions in non-diabetic overweight/obese Asian Indians in North India
The aim of the present study was to evaluate polymorphisms of fat mass and obesity (FTO; rs9939609) and vitamin D receptor (VDR, FokI (rs2228570), BsmI (rs1544410), ApaI (rs7975232), and TaqI (rs731236)] genes on...
-
Article
Open AccessDesigning of Carbon Nitride Supported ZnCo2O4 Hybrid Electrode for High-Performance Energy Storage Applications
This study reports a unique graphitic-C3N4 supported ZnCo2O4 composite, synthesized through a facile hydrothermal method to enhance the electrochemical performance of the electrode. The g-C3N4@ZnCo2O4 hybrid comp...
-
Article
Open AccessBempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy
High dose interleukin-2 (IL-2) is active against metastatic melanoma and renal cell carcinoma, but treatment-associated toxicity and expansion of suppressive regulatory T cells (Tregs) limit its use in patient...
-
Chapter and Conference Paper
Effect of Pile Layout and Pile Cap Thickness on Load Distribution in Piles
The paper illustrates, through practical examples, the effect of pile layout and pile cap thickness on the load distribution among different piles in a pile group. Study has been done considering square and re...
-
Article
Improved electrochemical performance of rGO/TiO2 nanosheet composite based electrode for supercapacitor applications
The present work reports the synthesis of a composite of TiO2 nanosheets (NS) with reduced graphene oxide (rGO) for supercapacitor applications. The formation of composite has been achieved via a simple one-pot h...
-
Article
Open AccessIntratumoral CD40 activation and checkpoint blockade induces T cell-mediated eradication of melanoma in the brain
CD40 agonists bind the CD40 molecule on antigen-presenting cells and activate them to prime tumor-specific CD8+ T cell responses. Here, we study the antitumor activity and mechanism of action of a nonreplicating ...
-
Article
Open AccessComputer-aided designing of immunosuppressive peptides based on IL-10 inducing potential
In the past, numerous methods have been developed to predict MHC class II binders or T-helper epitopes for designing the epitope-based vaccines against pathogens. In contrast, limited attempts have been made t...
-
Article
Open Access31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two
-
Article
Open AccessMycobacteria-responsive sonic hedgehog signaling mediates programmed death-ligand 1- and prostaglandin E2-induced regulatory T cell expansion
CD4+CD25+FoxP3+ regulatory T cells (Tregs) are exploited by mycobacteria to subvert the protective host immune responses. The Treg expansion in the periphery requires signaling by professional antigen presenting ...
-
Article
Open AccessL-tyrosine is a promising cancer vaccine adjuvant
-
Article
Basophils in autoimmune and inflammatory diseases
Basophils are classically known for their pathogenic role in asthma and allergic skin conditions. However, reports suggest that basophil activation mediated by autoreactive IgE, thymic stromal lymphopoietin or...
-
Article
Open AccessIntravenous immunoglobulin-induced IL-33 is insufficient to mediate basophil expansion in autoimmune patients
Intravenous immunoglobulin (IVIg) is used in the therapy of various autoimmune and inflammatory diseases. Recent studies in experimental models propose that anti-inflammatory effects of IVIg are mainly mediate...
-
Article
Human B cells induce dendritic cell maturation and favour Th2 polarization by inducing OX-40 ligand
Dendritic cells (DCs) play a critical role in immune homeostasis by regulating the functions of various immune cells, including T and B cells. Notably, DCs also undergo education on reciprocal signalling by th...
-
Article
Correction: Corrigendum: Circulating human basophils lack the features of professional antigen presenting cells
Recent reports in mice demonstrate that basophils function as antigen presenting cells (APC). They express MHC class II and co-stimulatory molecules CD80 and CD86, capture and present soluble antigens or IgE-a...
-
Article
Th17 cells, pathogenic or not? TGF-β3 imposes the embargo
-
Article
Open AccessCirculating human basophils lack the features of professional antigen presenting cells
Recent reports in mice demonstrate that basophils function as antigen presenting cells (APC). They express MHC class II and co-stimulatory molecules CD80 and CD86, capture and present soluble antigens or IgE-a...
-
Article
Inhibitory Effect of IVIG on IL-17 Production by Th17 Cells is Independent of Anti-IL-17 Antibodies in the Immunoglobulin Preparations
Th17 cells and their cytokines play a critical role in the pathogenesis of various autoimmune and inflammatory diseases. Recently, we have demonstrated that intravenous immunoglobulin (IVIG) suppresses differe...
-
Article
Open AccessHuman circulating basophils lack the features of professional antigen presenting cells
