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Article
Implications of Site‐specific Mass Absorption Cross‐section (MAC) to Black Carbon Observations at a High‐altitude Site in the Central Himalaya
Accurate estimation of black carbon (BC) from the widely used optical attenuation technique is important for the reliable assessment of their climatic impact. The optical instruments use Mass Absorption Cross-...
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In-situ Measurements of Aerosols from the High-Altitude Location in the Central Himalayas
Aerosols, both natural and anthropogenic, affect the Earth’s climate directly due to the absorption and scattering of solar radiation and indirectly by modifying the cloud microphysics. Due to the short lifeti...
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Article
Open AccessPlasmodium vivax msp-3α polymorphisms: analysis in the Indian subcontinent
Plasmodium vivax is the most widely distributed human malaria parasite and accounts for approximately the same number of malaria cases as Plasmodium falciparum in India. Compared with
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Article
Open AccessThe complexities of malaria disease manifestations with a focus on asymptomatic malaria
Malaria is a serious parasitic disease in the develo** world, causing high morbidity and mortality. The pathogenesis of malaria is complex, and the clinical presentation of disease ranges from severe and com...
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Article
Open AccessMutant pfcrt "SVMNT" haplotype and wild type pfmdr1 "N86" are endemic in Plasmodium vivax dominated areas of India under high chloroquine exposure
Chloroquine resistance (CQR) phenotype in Plasmodium falciparum is associated with mutations in pfcrt and pfmdr-1 genes. Mutations at amino acid position 72-76 of pfcrt gene, here defined as pfcrt haplotype are a...
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Article
Open AccessPlasmodium vivax lineages: geographical distribution, tandem repeat polymorphism, and phylogenetic relationship
Multi-drug resistance and severe/complicated cases are the emerging phenotypes of vivax malaria, which may deteriorate current anti-malarial control measures. The emergence of these phenotypes could be associa...
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Open AccessAntigenic repertoire of Plasmodium vivax transmission-blocking vaccine candidates from the Indian subcontinent
Genetic polymorphism is an inevitable component of a multistage infectious organism, such as the malaria parasite. By means of genetic polymorphism, parasite opts particular polymorph and reveals survival adva...
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Article
Open AccessMolecular epidemiology of Plasmodium vivax anti-folate resistance in India
Sulphadoxine and pyrimethamine are anti-folate drugs that show synergistic anti-malarial effect. Point mutations in dihydrofolate reductase (dhfr) and dihydropteorate synthatase (dhps) cause anti-folate drug resi...
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Article
Open AccessMultiple origins of resistance-conferring mutations in Plasmodium vivax dihydrofolate reductase
In order to maximize the useful therapeutic life of antimalarial drugs, it is crucial to understand the mechanisms by which parasites resistant to antimalarial drugs are selected and spread in natural populati...
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Open AccessPolymorphisms of TNF-enhancer and gene for FcγRIIa correlate with the severity of falciparum malaria in the ethnically diverse Indian population
Susceptibility/resistance to Plasmodium falciparum malaria has been correlated with polymorphisms in more than 30 human genes with most association analyses having been carried out on patients from Africa and sou...
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Article
Open AccessPolymorphism and epitope sharing between the alleles of merozoite surface protein-1 of Plasmodium falciparum among Indian isolates
The C-terminal region of merozoite surface protein-1 (MSP-1) is one of the leading candidates for vaccination against the erythrocytic stages of malaria. However, a major concern in the development of MSP-1 ba...
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Open AccessGenetic structure of Plasmodium falciparum field isolates in eastern and north-eastern India
Molecular techniques have facilitated the studies on genetic diversity of Plasmodium species particularly from field isolates collected directly from patients. The msp-1 and msp-2 are highly polymorphic markers a...
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Article
Development of nuclear DNA markers for evolutionary studies in Plasmodium falciparum
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Open AccessAllelic dimorphism of Plasmodium vivax gam-1 in the Indian subcontinent
Genetic polymorphism is an inevitable component of a complex organism especially in multistage infectious organisms such as malaria parasites. Understanding the population genetic structure of the parasites wo...
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Article
Effect of nitrogen fertilizer on biomass and growth behaviour of two range grasses
The effect of four levels of nitrogen (0, 20, 40 and 80 ppm) on the growth behaviour of two range grasses (i.e.Lolium perenne andPoa pratensis) was studied. The application of different doses of fertilizer increa...
