-
Article
Open AccessCOIL: a methodology for evaluating malarial complexity of infection using likelihood from single nucleotide polymorphism data
Complex malaria infections are defined as those containing more than one genetically distinct lineage of Plasmodium parasite. Complexity of infection (COI) is a useful parameter to estimate from patient blood sam...
-
Article
The malaria parasite Plasmodium vivax exhibits greater genetic diversity than Plasmodium falciparum
Jane Carlton and colleagues report the genome sequencing, de novo assembly and annotation of four Plasmodium vivax reference strains from diverse geographic locations. Their cross-species comparisons show that P....
-
Article
Open AccessHybrid selection for sequencing pathogen genomes from clinical samples
We have adapted a solution hybrid selection protocol to enrich pathogen DNA in clinical samples dominated by human genetic material. Using mock mixtures of human and Plasmodium falciparum malaria parasite DNA as ...
