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Article
Open AccessImproved cytosine base editors generated from TadA variants
Cytosine base editors (CBEs) enable programmable genomic C·G-to-T·A transition mutations and typically comprise a modified CRISPR–Cas enzyme, a naturally occurring cytidine deaminase, and an inhibitor of uraci...
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Article
Open AccessCytosine base editors with minimized unguided DNA and RNA off-target events and high on-target activity
Cytosine base editors (CBEs) enable efficient, programmable reversion of T•A to C•G point mutations in the human genome. Recently, cytosine base editors with rAPOBEC1 were reported to induce unguided cytosine ...
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Article
Deep learning using tumor HLA peptide mass spectrometry datasets improves neoantigen identification
Neoantigen prediction from clinical samples is improved using a neural network model trained on a large HLA peptide and genomic tumor dataset.
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Article
Open AccessTargeted genomic landscape of metastases compared to primary tumours in clear cell metastatic renal cell carcinoma
The genomic landscape of primary clear cell renal cell carcinoma (ccRCC) has been well described. However, little is known about cohort genomic alterations (GA) landscape in ccRCC metastases, or how it compare...
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Article
Human Papillomavirus Vaccine Knowledge and Attitudes, Preventative Health Behaviors, and Medical Mistrust Among a Racially and Ethnically Diverse Sample of College Women
Medical mistrust is associated with disparities in a variety of health outcomes. The human papillomavirus (HPV) vaccine has the potential to decrease disparities in cervical cancer by preventing infection with...
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Article
The malaria parasite Plasmodium vivax exhibits greater genetic diversity than Plasmodium falciparum
Jane Carlton and colleagues report the genome sequencing, de novo assembly and annotation of four Plasmodium vivax reference strains from diverse geographic locations. Their cross-species comparisons show that P....
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Article
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies
Ken Ong and colleagues report meta-analysis of 32 genome-wide association studies for age at menarche. They identify 30 loci newly associated with age at menarche, including four that were previously associate...
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Article
A Cohort-Driven Assessment Task for Scientific Report Writing
A formative assessment task was developed to improve the scientific report writing skills of university students. Students undertaking this task typically possessed varying levels of scientific literacy and we...
