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Article
Determination of Methylphosphonic Acid and Alkyl Methylphosphonic Acid Esters in Soils by Liquid Chromatography–High-Resolution Mass Spectrometry
A method has been optimized for simultaneous extraction of ethyl methylphosphonic acid ester (EMPA), isopropyl methylphosphonic acid ester (IPMPA), isobutyl methylphosphonic acid ester (IBMPA), pinacolyl methy...
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Article
Determination of Hydrolytic Transformation Products of Sesquimustards in Water by High Resolution Liquid Chromatography/Mass Spectrometry
An approach to the determination of five sesquimustard markers, namely, bis(2-hydroxyethylthio)methane (BHETM), 1,2-bis(2-hydroxyethylthio)ethane (BHETE), 1,3-bis(2-hydroxyethylthio)-n-propane (BHETPr), 1,4-bis(2...
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Article
Determination of Nitrogen Mustard Metabolites in Urine Using High-Performance Liquid Chromatography–High-Resolution Mass Spectrometry
Liquid chromatography–high-resolution mass spectrometry that combines the capabilities of highly selective separation of mixtures under study, valid detection of unknown substances, and high sensitivity is wid...
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Article
Determination of p-Methoxyphenacyl Bromide Derivatives of Alkylmethylphosphonic Acids in Urine Using Gas Chromatography with High-Resolution Mass Spectrometric Detection
We developed a method for determining ethyl methylphosphonic, isopropyl methylphosphonic, isobutyl methylphosphonic, and pinacolyl methylphosphonic acids in human urine using gas chromatography with high-resol...
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Article
Characteristics of a High-Resolution Mass Spectrum of an Adduct of 2-(Diethylamino)Ethylthiol with a Dipeptide (Cys–Pro)
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Article
Identification of Adducts of O-Isopropylmethylphosphonic and O-Cyclohexylmethylphosphonic Acids with a Tripeptide (Tyr-Thr-Lys) in Human Plasma by Liquid Chromatography–Mass Spectrometry
We proposed a method for determining the presence of trace amounts of adducts of isopropylmethylphosphonic acid (IMPA) and cyclohexylmethylphosphonic acid (CMPA), biomarkers of exposure to sarin and cyclosarin...
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Article
Determination of Eleutheroside B and Eleutheroside E in Extracts from Eleutherococcus senticosus by Liquid Chromatography/Mass Spectrometry
Eleutherococcus senticosus is a plant with medicinal properties due to the presence of glycosides, called eleutherosides А, В and В1, C, D, E, and F, in its roots and rhizomes. In this paper, a procedure for the ...
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Article
p-Methoxyphenacyl Bromide as a Versatile Reagent for the Determination of Alkylphosphonic and Alkylmethylphosphonic Acids by High-Performance Liquid and Gas Chromatography with Mass Spectrometric Detection
A multipurpose reagent, p-methoxyphenacyl bromide, is proposed for the derivatization of polar products of the degradation (markers) of nerve agents, which allows their determination by high-performance liquid ch...
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Article
Determination of Cyclohexylmethylfluorophosphonate Metabolites in Human Blood Plasma Using High-Resolution Liquid Chromatography–Mass Spectrometry
Conditions for the extraction of a phosphonylated nonapeptide, phosphonylated tyrosine, and cyclohexylmethylphosphonic acid from human blood plasma followed by HPLC determination with detection by high-resolut...
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Article
Selection of Recording Conditions and Study of Fragmentation of a Peptide Biomarker of Sarin by High-Performance Liquid Chromatography–High-Resolution Mass Spectrometry
The identification of protein biomarkers of chemical warfare agents involves their reliable detection in the blood plasma at trace levels. This is a challenging task in the modern liquid chromatography–mass sp...
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Article
Detection of Ricin in Plant Extracts and Soil Using Liquid Chromatography–High-Resolution Mass Spectrometry
A procedure is developed for the detection of ricin in plant extracts and soil based on its hydrolysis with trypsin and chymotrypsin with the formation of specific peptides and their determination by HPLC with...
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Article
Determination of Methylphosphonic Acid in Human Blood Plasma by High-Performance Liquid Chromatography–Tandem Mass Spectrometry
Using high-performance liquid chromatography combined with tandem mass spectrometric detection, an approach has been developed for the determination of the most stable nerve agent biomarker, methylphosphonic a...
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Article
Time-Efficient LC/MS/MS Determination of Low Concentrations of Methylphosphonic Acid
A time-efficient protocol for quantification of methylphosphonic acid (MPA), a final hydrolysis product of nerve agents in aqueous environments, via liquid chromatography mass spectrometry is described. Chroma...
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Article
Optimization of a method for the determination of a mustard gas biomarker in human blood plasma by liquid chromatography–high-resolution mass spectrometry
A method for the determination of a mustard gas biomarker (an S-hydroxyethylthioethyl adduct with albumin) in blood plasma was optimized with the use of HPLC with high-resolution tandem mass-spectrometric dete...
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Article
Determination of 2-chlorovinylarsonous acid and 2-chlorovinylarsonic acid in water by capillary electrophoresis with direct spectrophotometric detection
An approach for determining 2-chlorovinylarsonous acid and 2-chlorovinylarsonic acid (decomposition products of such blister agent as lewisite) in water by capillary zone electrophoresis was proposed. The cond...
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Article
Determination of the hydrolysis products of nerve agents in natural waters by liquid chromatography–mass spectrometry
An approach to the determination of markers of the application of four nerve agents, S-(2-diethylaminoethyl)methylphosphonothioate, S-(2-diisopropylaminoethyl)methylphosphonothioate, bis(2N,N-diethylaminoethyl)di...
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Article
Simultaneous determination of ginsenosides by high-performance liquid chromatography with tandem mass spectrometry detection
An approach to the simultaneous registration of ginsenosides in herbal extracts and commercial products was developed on the basis of liquid chromatography/mass spectrometry. The approach was validated for fou...
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Article
HPLC-MS/MS determination of biomarkers of P. quinquefolius in plant materials and commercial products
An approach to the detection of ginsenosides in plant extracts and commercial products is developed on the basis of liquid chromatography/mass spectrometry. The approach was validated for two major ginsenoside...
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Article
Modern methods of identifying and determining ginsenosides
Ginsenosides are the main bioactive compounds of the Panax plant genus. Ginseng and its analogues are widely used to produce traditional medicines in China, Korea, Japan, United States, and the Russian Far East. ...
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Article
Simultaneous determination of salidroside, rosavin, and rosarin in extracts from Rhodiola rosea by high performance liquid chromatography with tandem mass spectrometry detection
An approach is developed for the simultaneous determination of salidroside, rosarin, and rosavin in extracts from plant based on liquid chromatography/mass spectrometry; the detection limits of the method are ...
