28 Result(s)

Article

Structure analysis of the extracellular domain reveals disulfide bond forming-protein properties of Mycobacterium tuberculosis Rv2969c

Disulfide bond-forming (Dsb) protein is a bacterial periplasmic protein that is essential for the correct folding and disulfide bond formation of secreted or cell wallassociated proteins. DsbA introduces disul...

Lu Wang, Jun Li, **angxi Wang, Wu Liu, Xuejun C. Zhang, Xuemei Li… in Protein & Cell (2013)

Article

An open conformation determined by a structural switch for 2A protease from coxsackievirus A16

Coxsackievirus A16 belongs to the family Picornaviridae, and is a major agent of hand-foot-and-mouth disease that infects mostly children, and to date no vaccines or antiviral therapies are available. 2A protease...

Yao Sun, **angxi Wang, Shuai Yuan, Minghao Dang, Xuemei Li… in Protein & Cell (2013)

Article

Molecular mechanism of SCARB2-mediated attachment and uncoating of EV71

Unlike the well-established picture for the entry of enveloped viruses, the mechanism of cellular entry of non-enveloped eukaryotic viruses remains largely mysterious. Picornaviruses are representative models ...

Minghao Dang, **angxi Wang, Quan Wang, Yaxin Wang, Jian** Lin, Yuna Sun… in Protein & Cell (2014)

Article

PTEN regulates RPA1 and protects DNA replication forks

Tumor suppressor PTEN regulates cellular activities and controls genome stability through multiple mechanisms. In this study, we report that PTEN is necessary for the protection of DNA replication forks agains...

Guangxi Wang, Yang Li, Pan Wang, Hui Liang, Ming Cui, Minglu Zhu… in Cell Research (2015)

Article

TIM-1 acts a dual-attachment receptor for Ebolavirus by interacting directly with viral GP and the PS on the viral envelope

Ebolavirus can cause hemorrhagic fever in humans with a mortality rate of 50%–90%. Currently, no approved vaccines and antiviral therapies are available. Human TIM1 is considered as an at...

Shuai Yuan, Lei Cao, Hui Ling, Minghao Dang, Yao Sun, Xuyuan Zhang… in Protein & Cell (2015)

Article

The binding of a monoclonal antibody to the apical region of SCARB2 blocks EV71 infection

Entero virus 71 (EV71) causes hand, foot, and mouth disease (HFMD) and occasionally leads to severe neurological complications and even death. Scavenger receptor class B member 2 (SCARB2) is a functional recep...

Xuyuan Zhang, Pan Yang, Nan Wang, Jialong Zhang, **gyun Li, Hao Guo… in Protein & Cell (2017)

Article

Structures of the portal vertex reveal essential protein-protein interactions for Herpesvirus assembly and maturation

Nan Wang, Wenyuan Chen, Ling Zhu, Dongjie Zhu, Rui Feng, Jialing Wang… in Protein & Cell (2020)

Article

Architecture of the herpesvirus genome-packaging complex and implications for DNA translocation

Genome packaging is a fundamental process in a viral life cycle and a prime target of antiviral drugs. Herpesviruses use an ATP-driven packaging motor/terminase complex to translocate and cleave concatemeric d...

Yunxiang Yang, Pan Yang, Nan Wang, Zhonghao Chen, Dan Su, Z. Hong Zhou… in Protein & Cell (2020)

Article

Structure-based development of human antibody cocktails against SARS-CoV-2

Nan Wang, Yao Sun, Rui Feng, Yuxi Wang, Yan Guo, Li Zhang, Yong-Qiang Deng… in Cell Research (2021)

Article

Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection

Structural principles underlying the composition and synergistic mechanisms of protective monoclonal antibody cocktails are poorly defined. Here, we exploited antibody cooperativity to develop a therapeutic an...

Hang** Yao, Yao Sun, Yong-Qiang Deng, Nan Wang, Yongcong Tan… in Cell Research (2021)

Article

Structure-based development of three- and four-antibody cocktails against SARS-CoV-2 via multiple mechanisms

Yao Sun, Lei Wang, Rui Feng, Nan Wang, Yuxi Wang, Dandan Zhu, **aorui **ng… in Cell Research (2021)

Article

Structural basis for neutralization of an anicteric hepatitis associated echovirus by a potent neutralizing antibody

Rui Feng, Lei Wang, Dawei Shi, Binyang Zheng, Li Zhang, Hai Hou, Deju **a… in Cell Discovery (2021)

Article

Publisher Correction: SARS-CoV-2 spike protein interacts with and activates TLR4

A Correction to this paper has been published: https://doi.org/10.1038/s41422-021-00501-0

Yingchi Zhao, Ming Kuang, Junhong Li, Ling Zhu, Zi**g Jia, Xuefei Guo… in Cell Research (2021)

Article

SARS-CoV-2 spike protein interacts with and activates TLR41

Yingchi Zhao, Ming Kuang, Junhong Li, Ling Zhu, Zi**g Jia, Xuefei Guo… in Cell Research (2021)

Article

Sequential immunizations confer cross-protection against variants of SARS-CoV-2, including Omicron in Rhesus macaques

Variants of concern (VOCs) like Delta and Omicron, harbor a high number of mutations, which aid these viruses in esca** a majority of known SARS-CoV-2 neutralizing antibodies (NAbs). In this study, Rhesus macaq...

Wei Deng, Qi Lv, Fengdi Li, Jiangning Liu… in Signal Transduction and Targeted Therapy (2022)

Article

Structural and molecular basis for foot-and-mouth disease virus neutralization by two potent protective antibodies

Hu Dong, Pan Liu, Manyuan Bai, Kang Wang, Rui Feng, Dandan Zhu, Yao Sun… in Protein & Cell (2022)