17 Result(s)

Article

Divergent engagements between adeno-associated viruses with their cellular receptor AAVR

Adeno-associated virus (AAV) receptor (AAVR) is an essential receptor for the entry of multiple AAV serotypes with divergent rules; however, the mechanism remains unclear. Here, we determine the structures of ...

Ran Zhang, Guangxue Xu, Lin Cao, Zixian Sun, Yong He, Mengtian Cui… in Nature Communications (2019)

Article

CARK1 mediates ABA signaling by phosphorylation of ABA receptors

The function of abscisic acid (ABA) is mediated by its receptors termed RCARs/PYR1/PYLs. Modulation of ABA signaling is vital for plant growth and development. The RCAR-PP2C-SnRK2 regulatory modules have been ...

Liang Zhang, **aoyi Li, Dekuan Li, Yuna Sun, Ying Li, Qin Luo, Zhibin Liu… in Cell Discovery (2018)

Article

Erratum to: A comprehensive procedure for antiviral inhibitor discovery using EV71 as an example

Lin Cao, Shouhai Zhu, Yaxin Wang, Zhiyong Lou, Yuna Sun in Biophysics Reports (2016)

Article

A comprehensive procedure for antiviral inhibitor discovery using EV71 as an example

The prevalence of chronic viral infectious diseases, the emergence and re-emergence of new viral infections, and in particular, resistance to currently used antiviral drugs have led to increased demand for new...

Lin Cao, Shouhai Zhu, Yaxin Wang, Zhiyong Lou, Yuna Sun in Biophysics Reports (2015)

Article

Molecular basis for the inhibition of β-hydroxyacyl-ACP dehydratase HadAB complex from Mycobacterium tuberculosis by flavonoid inhibitors

Dehydration is one of the key steps in the biosynthesis of mycolic acids and is vital to the growth of Mycobacterium tuberculosis (Mtb). Consequently, stalling dehydration cures tuberculosis (TB). Clinically used...

Yu Dong, **aodi Qiu, Neil Shaw, Yueyang Xu, Yuna Sun, Xuemei Li, Jun Li… in Protein & Cell (2015)

Article

Crystal structure of the novel di-nucleotide cyclase from Vibrio cholerae (DncV) responsible for synthesizing a hybrid cyclic GMP-AMP

Zhenhua Ming, Wei Wang, Yuchen **e, Pengfei Ding, Yuchao Chen, Dazhi **… in Cell Research (2014)

Article

Molecular mechanism of SCARB2-mediated attachment and uncoating of EV71

Unlike the well-established picture for the entry of enveloped viruses, the mechanism of cellular entry of non-enveloped eukaryotic viruses remains largely mysterious. Picornaviruses are representative models ...

Minghao Dang, **angxi Wang, Quan Wang, Yaxin Wang, Jian** Lin, Yuna Sun… in Protein & Cell (2014)

Article

The nucleoprotein of severe fever with thrombocytopenia syndrome virus processes a stable hexameric ring to facilitate RNA encapsidation

Severe fever with thrombocytopenia syndrome virus (SFTSV), a member of the Phlebovirus genus from the Bunyaviridae family endemic to China, is the causative agent of life-threatening severe fever with thrombocyto...

Honggang Zhou, Yuna Sun, Ying Wang, Min Liu, Chao Liu, Wenming Wang… in Protein & Cell (2013)

Article

A versatile building block: the structures and functions of negative-sense single-stranded RNA virus nucleocapsid proteins

Nucleocapsid protein (NPs) of negative-sense single-stranded RNA (-ssRNA) viruses function in different stages of viral replication, transcription, and maturation. Structural investigations show that -ssRNA vi...

Yuna Sun, Yu Guo, Zhiyong Lou in Protein & Cell (2012)

Article

Structural basis for the impact of phosphorylation on the activation of plant receptor-like kinase BAK1

Liming Yan, Yuanyuan Ma, Dan Liu, **aochao Wei, Yuna Sun, **aoyue Chen… in Cell Research (2012)

Article

A structural view of the antibiotic degradation enzyme NDM-1 from a superbug

Gram-negative Enterobacteriaceae with resistance to carbapenem conferred by New Delhi metallo-β-lactamase 1 (NDM-1) are a type of newly discovered antibioticresistant bacteria. The rapid pandemic spread of NDM-1 ...

Yu Guo, **g Wang, Guojun Niu, Wenqing Shui, Yuna Sun, Honggang Zhou… in Protein & Cell (2011)

Article

Crystal structure of a secreted lipase from Gibberella zeae reveals a novel “double-lock” mechanism

Fusarium graminearum (sexual stage: Gibberella zeae) is the causative agent of Fusarium Head Blight (FHB), which is one of the most destructive plant disease of cereals, accounting for high grain yield losses, es...

Zhiyong Lou, Ming Li, Yuna Sun, Ye Liu, Zheng Liu, Wen** Wu, Zihe Rao in Protein & Cell (2010)

Article

A novel non-radioactive assay for HIV-RT (RdDp) based on pyrosequencing for high-throughput drug screening

Current in vitro assays for the activity of HIV-RT (reverse transcriptase) require radio-labeled or chemically modified nucleotides to detect reaction products. However, these assays are inherently end-point meas...

Chang Zhang, Yang Wu, Yuna Sun, Chuan Hong, Kehui **ang, Yu Guo… in Protein & Cell (2010)