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Article
Open AccessMolecular insights into DNA recognition and methylation by non-canonical type I restriction-modification systems
Type I restriction-modification systems help establish the prokaryotic DNA methylation landscape and provide protection against invasive DNA. In addition to classical m6A modifications, non-canonical type I en...
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Article
Open AccessStructural basis for neutralization of an anicteric hepatitis associated echovirus by a potent neutralizing antibody
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Article
Structure of the HRV-C 3C-Rupintrivir Complex Provides New Insights for Inhibitor Design
Human rhinoviruses (HRVs) are the predominant infectious agents for the common cold worldwide. The HRV-C species cause severe illnesses in children and are closely related to acute exacerbations of asthma. 3C ...
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Article
Open AccessEffects of SDS on the activity and conformation of protein tyrosine phosphatase from thermus thermophilus HB27
Deciphering the activity-conformation relationship of PTPase is of great interest to understand how PTPase activity is determined by its conformation. Here we studied the activity and conformational transition...
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Article
Open AccessAn ignored variable: solution preparation temperature in protein crystallization
Protein crystallization is affected by many parameters, among which certain parameters have not been well controlled. The temperature at which the protein and precipitant solutions are mixed (i.e., the ambient...
