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Article
Knockdown of EIF2AK2-OAS1 axis reduces ATP production inducing AMPK phosphorylation to inhibit the malignant behavior of gastric cancer cells
Energy metabolism has always been a hot topic in cancer progression and targeted therapy, and exploring the role of genes in energy metabolic pathways in cancer cells has become key to address this issue. Euka...
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Article
Open AccessThreshold of hyperglycaemia associated with mortality in critically ill patients: a multicentre, prospective, observational study using continuous glucose monitoring
Continuous glucose monitoring (CGM) provides comprehensive information on the exposure to dysglycaemia. This study aimed to investigate the threshold of hyperglycaemia related to mortality risk in critically i...
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Article
Association of sudomotor dysfunction with risk of diabetic retinopathy in patients with type 2 diabetes
Sudomotor dysfunction is considered as one of the earliest manifestations of diabetic peripheral neuropathy. We aimed to investigate the association between sudomotor dysfunction non-invasively detected by the...
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Article
Continuous glucose monitoring profile in COVID-19 patients with and without diabetes receiving methylprednisolone
Methylprednisolone is widely used during the COVID-19 epidemic. We aimed to evaluate the glucose profile of COVID-19 patients with and without diabetes receiving methylprednisolone.
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Article
Open AccessMediating effect of gestational weight gain on the preventive effect of exercise during pregnancy on macrosomia: a randomized clinical trial
We sought to investigate the impact of individualized exercise guidance during pregnancy on the incidence of macrosomia and the mediating effect of gestational weight gain (GWG).
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Article
DDLA: a double deep latent autoencoder for diabetic retinopathy diagnose based on continuous glucose sensors
The current diagnosis of diabetic retinopathy is based on fundus images and clinical experience. However, considering the ineffectiveness and non-portability of medical devices, we aimed to develop a diagnosti...
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Article
Open AccessPreoperatively predicting the lymph node metastasis and prognosis for gastric cancer patients
The preoperative distinguishment of lymph nodes (LN) with metastasis plays a pivotal role in guiding the surgical extension for gastric cancer (GC). We aim to identify the preparative risk factors for LN metas...
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Article
A Novel Approach for Delivery of Ergosterol Within Ferritin Cage: Stability, Slow-Release Property, and Cholesterol-Lowering Effect After Simulated Gastrointestinal Digestion
Ergosterol possesses a variety of physiological activities, however, its application is limited due to its poor water solubility and photosensitivity. In this study, by using the ultrasonic-assisted heating me...
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Article
Immune Response Gene-1 [IRG1]/itaconate protect against multi-organ injury via inhibiting gasdermin D-mediated pyroptosis and inflammatory response
Sepsis is a multiple organ dysfunction syndrome due to a dysregulated response to infection with unacceptably high mortality. Currently, no effective treatment exists for sepsis. IRG1/itaconate has been consid...
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Article
Personalized Numerical Cardiovascular Model with Weight Growth for Evaluating Pediatric Left Ventricular Assist Devices: Derivation from an Experimental Mock Circulatory Loop
Pediatric patients with heart failure have limited treatment options because of a shortage of donor hearts and compatible left ventricular assist devices (LVADs). To address this issue, our group is develo**...
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Article
Open AccessFault Diagnosis of Wastewater Treatment Processes Based on CPSO-DKPCA
The wastewater treatment process (WWTP) is one of the most common links in chemical plants. However, the testing for diagnosing faults in wastewater treatment plants is expensive and time-consuming. Due to str...
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Article
Open AccessEffects of small-dose S-ketamine on anesthesia-induced atelectasis in patients undergoing general anesthesia accessed by lung ultrasound: study protocol for a randomized, double-blinded controlled trial
Atelectasis after anesthesia induction in most patients undergoing general anesthesia may lead to postoperative pulmonary complications (PPCs) and affect postoperative outcomes. However, there is still no exis...
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Article
Open AccessHelical-caging enables single-emitted large asymmetric full-color circularly polarized luminescence
Colorful circularly polarized luminescence materials are desired for 3D displays, information security and asymmetric synthesis, in which single-emitted materials are ideal owing to self-absorption avoidance, ...
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Chapter and Conference Paper
Electrically-Assisted Incremental Forming of Invar 36 Sheet
The Invar 36 alloy is widely used in aerospace and precision instruments for its extremely low coefficient of thermal expansion below Curie temperature (230 ℃). The conventional method of manufacturing Invar m...
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Article
Alterations of outer retinal reflectivity in diabetic patients without clinically detectable retinopathy
This study aimed to investigate alterations of outer retinal reflectivity on spectral-domain optical coherence tomography (OCT) in diabetic patients without clinically detectable retinopathy (NDR).
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Article
Open AccessMetabolite itaconate in host immunoregulation and defense
Metabolic states greatly influence functioning and differentiation of immune cells. Regulating the metabolism of immune cells can effectively modulate the host immune response. Itaconate, an intermediate metab...
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Article
Synthesis of MOF-derived porous multi-metal/carbon composites by metal regulation strategy for efficient microwave absorption application
The combination of carbon and ferrimagnet metallic materials derived from metal-organic frameworks (MOFs) have received increasing research interest for high performance electromagnetic wave absorption (EMA) m...
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Article
Open AccessEfficacy of Poria cocos and Alismatis rhizoma against diet-induced hyperlipidemia in rats based on transcriptome sequencing analysis
Hyperlipidemia, a common metabolic disease, is a risk factor for cardiovascular diseases, Poria cocos (PC) and Alismatis rhizoma (AR) serve as a potential treatment. A systematic approach based on transcriptome s...
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Article
Open AccessRegulating interfacial reaction through electrolyte chemistry enables gradient interphase for low-temperature zinc metal batteries
In situ formation of a stable interphase layer on zinc surface is an effective solution to suppress dendrite growth. However, the fast transport of bivalent Zn-ions within the solid interlayer remains very cha...
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Article
Open AccessDeterminants of incident atherosclerotic cardiovascular disease events among individuals with type 2 diabetic microvascular complications in the UK: a prospective cohort study
To evaluate the association of atherosclerotic cardiovascular disease (ASCVD) risk factors with incident ASCVD events among type 2 diabetes (T2D) individuals with microvascular complications.
