13 Result(s)
within
Chapter
Ke** Zhang
Human Genetics
Pharmacology/Toxicology
-
Chapter
Immunological Methods for the Detection of Polycyclic Aromatic Hydrocarbon-DNA and Protein Adducts
Sensitive immunological methods are now available for the detection and quantitation of carcinogen-DNA and protein adducts. Both monoclonal and polyclonal antibodies have been developed against DNA modified by...
-
Chapter
5-Fluoro-2′-Deoxyuridine: Role of Schedule in its Therapeutic Efficacy
The fluorinated pyrimidines 5-fluorouracil (FUra) and 5-fluoro-2′-deoxyuridine (FdUrd) are drugs that have been shown to have clinical activity against colorectal carcinoma and other malignancies. Attempts to ...
-
Chapter
Comparing Porcine Models of Coronary Restenosis
The use of swine to study the vascular response to injury has gained wide acceptance over the past 10 yr. Our approach to the porcine model has been focused on the evaluation of novel therapeutic approaches to...
-
Chapter
Liposome-Mediated Delivery of Genes and Oligonucleotides for the Treatment of Brain Tumors
Brain tumors present a great therapeutic challenge due to their very poor prognosis (Mahaley et al, 1989). On the other hand, brain tumors have some features that make them particularly attractive for in vivo ...
-
Chapter
Prenatal and Perinatal Development of Intestinal Transport and Brush Border Hydrolases in Pigs
Although the neonatal intestine is able to process milk and absorb the components, problems of digestion are common. Because of the limited availability of human fetal and neonatal tissues, relatively little i...
-
Chapter
Evaluation of the Reliability of cDNA Microarray Technique
-
Chapter
Microfabricated Chip Electrophoresis Technology for DNA Analysis
In this report, two microfabricated chip electrophoresis techniques and several application studies were tested for rapid and high-resolution separation of double-stranded (ds)DNA. In one technique, low-viscos...
-
Chapter
The Application of Novel Multi-Functional Microarray Slides for Immobilization Biomolecules
Microarray has revolutionized the study of molecular biology, especially the application in clinical diagnostics. When used in clinical diagnostics, microarray has to meet a high degree of reproducibility, rel...
-
Chapter
An Integrated Biochemoinformatics System for Drug Discovery
Chipscreen Biosciences, Ltd. (www.chipscreen.com) is a drug discovery company specialized in novel small molecule therapeutics. Chipscreen has developed a proprietary chemical genomics approach to accelerate t...
-
Chapter
Pregnancy Exposures Determine Risk of Breast Cancer in Multiple Generations of Offspring
Breast cancer is the most common non-skin cancer in women in the United States. The incidence rate of breast cancer among migrant women from Asian countries, where the breast cancer incidence is low, could ach...
-
Chapter
Pharmacomicrobiomics
The safety and efficacy of drugs are the key issues in clinical treatment. Classical pharmacogenomics cannot fully explain the individual differences of drug responses. Pertinent studies indicate that intestin...
-
Chapter
The Ethical, Legal, and Regulatory Issues Associated with Pharmacogenomics
Developed with more and more implementation of pharmacogenomics (PGx), both in clinics and extended to some testing companies, more and more issues related have arisen, as ever-increasing participants from all...
-
Chapter
Pharmacogenomics of Anti-Infective Agents
Ever since we know that the dissimilarities of medications are influenced by the in vivo process of the body, including absorption, distribution, metabolization, and excretion, great attentions have been paid ...
