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Chapter and Conference Paper
Slow Progression of Neurologic Impairment after Mild Ischemic Insult in Rodents: Relationship to Metabolic and Histologic Changes
We assessed the relationship between slowly progressing neurologic impairment and metabolic and morphologic changes in two rodent models of mild cerebral ischemia. Mild ischemia was induced by occluding the co...
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Chapter and Conference Paper
Transgenic Mutants for the Investigation of Molecular Stroke Mechanisms
Brain damage induced by focal interruption of blood flow can be differentiated in two pathophysiologically different categories: a hemodynamic type of injury, resulting in primary necrotic brain damage, and a ...
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Chapter and Conference Paper
Relationship Between DNA Fragmentation, Energy State, and Protein Synthesis After Transient Focal Cerebral Ischemia in Mice
The effects of post-ischemic recirculation on regional cerebral metabolism and DNA fragmentation was examined in mice subjected to 30 min, 1 h or 2 h transient middle cerebral artery occlusion (MCAO) followed ...
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Chapter and Conference Paper
Evolution of Energy Failure after Repeated Cerebral Ischemia in Gerbils
We have examined the regional differences in the evolution of energy failure in experimental focal cerebral ischemia. In gerbil brain subjected to repeated unilateral common carotid artery occlusion, the tissu...
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Chapter and Conference Paper
Mitochondrial Dysfunction and Maturation Phenomenon in Ischemic Gerbil Cortex
We examined the time course of energy impairment in the cerebral cortex, which develops cerebral infarction after repeated ischemia. Cerebral ischemia was induced in the gerbil by repeated unilateral carotid-a...
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Chapter and Conference Paper
Metabolic Disturbances and Gene Responses Following Cortical Injury in Rats: Relationship to Spreading Depression
The effects of a cortex lesion on alterations in cortical direct-current (DC) potential, cerebral metabolism and gene expression were examined in rats at 1–6 h after transcranial cold injury. In 14 of 21 injur...
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Chapter and Conference Paper
Modulation of Protein Synthesis and Calcium Uptake Following Traumatic Lesion of Rat Brain Cortex
Following cold lesion of rat brain cortex, the time course of regional cerebral protein synthesis (CSP) and cerebral calcium uptake (CCU) was assessed in the same animal using [3H]leucine and 45CaCl by means of d...
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Chapter and Conference Paper
Insight into the Protective Mechanisms of Cortical Spreading Depression in Cardiac Arrest Cerebral Ischemia in Rat
Cortical spreading depression has recently been shown to protect hippocampal CA1 pyramidal neurons, as well as cortical neurons, against ischemic damage if elicited prior to ischemia. The present study was und...
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Chapter
Autoradiographic and Biochemical Imaging in Cerebral Ischemia
The central nervous system consists of innumerable anatomical subunits, each of which participate in one or several functional activities during the normal state of the brain. The maintenance of cerebral activ...
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Chapter and Conference Paper
Possible Role of Intracellular Calcium Translocation in the Maturation of Ischemic Damage
The fine structural localization of calcium was studied in 3-month-old female Mongolian gerbils (Meriones unguiculatus) subjected to single 5-min bilateral common carotid artery occlusions. Intracellular calcium ...
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Chapter and Conference Paper
Protein Synthesis and Calcium Uptake Following Complete Cerebral Ischemia of Rat Brain
The possible involvement of neuroexcitatory pathomechanisms in the development of postischemic neuron injury was examined in rats subjected to 10-min cardiac arrest for the induction of complete cerebral ische...
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Chapter and Conference Paper
Role of Neuroexcitation in Development of Blood-Brain Barrier and Oedematous Changes Following Cerebral Ischaemia and Traumatic Brain Injury
Potential involvement of neuroexcitatory mechanisms was studied in: 1) repetitive forebrain ischaemia in gerbils, 2) global cerebral ischaemia in rats and 3) cryogenic injury to the cerebral cortex in rats and...
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Chapter and Conference Paper
Regional Hemodynamic and Metabolic Disturbances in Experimental Cerebral Ischemia
Measurements of regional blood flow and metabolism have proved to be of considerable interest for evaluating the size and severity of tissue damage following stroke. Therefore, various clinical imaging techniq...
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Chapter
Neuropathology and Regional Imaging of Microcirculation, Tissue pH, Metabolites and Necroses in Cerebral RG2 and F98 Anaplastic Rat Glioma Transplantation Tumors
Malignant human gliomas corresponding to grade III and IV are anaplastic ependymomas, anaplastic astrocytomas, anaplastic oligodendrogliomas, anaplastic mixed gliomas and the glioblastoma group (WHO classifica...
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Chapter and Conference Paper
Regional Evaluation of Blood Flow and Metabolism in Experimental Brain Tumor of Rats
Development of brain tumors is associated with hemodynamic and metabolic disturbances of the brain, Partly because of local interference by tumor and peritumoral edema, and Partly because of general effects du...
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Chapter
Experimental Application of Triple-Labeled Quantitative Autoradiography for Measurement of Cerebral Blood Flow, Glucose Metabolism, and Protein Biosynthesis
During the past years autoradiographic techniques for measuring blood flow (Reivich et al. 1969; Sakurada et al. 1978) and metabolic activity (Sokoloff et al. 1977) have been of increasing interest in the stud...
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Chapter
Discrepancy Between Glucose Availability and Calculated Glucose Consumption During Acute Brain Ischemia
Vascular occlusion of the common carotid artery in the gerbil (Meriones unguiculatus) is a well-established animal brain infarction model. We have used a modification of this method (Bosma et al. 1981) in order t...
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Chapter
Pathophysiology and Pathobiochemistry of Acute Brain Infarction in the Gerbil: The Influence of Metabolic Inhibition
The understanding of the pathophysiology of stroke requires the use of experimental models which under standardized conditions are able to mimic the clinical situation as closely as possible. Among the various...
