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Chapter and Conference Paper
Transgenic Mutants for the Investigation of Molecular Stroke Mechanisms
Brain damage induced by focal interruption of blood flow can be differentiated in two pathophysiologically different categories: a hemodynamic type of injury, resulting in primary necrotic brain damage, and a ...
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Article
Adenovirus-mediated overexpression of a gene prevents hearing loss and progressive inner hair cell loss after transient cochlear ischemia in gerbils
The use of adenoviral vectors has recently provided a novel strategy for direct gene transfer into the cochlea. In this study, we assessed the utility of an adenoviral vector expressing glial-cell-derived neur...
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Chapter and Conference Paper
Relationship Between DNA Fragmentation, Energy State, and Protein Synthesis After Transient Focal Cerebral Ischemia in Mice
The effects of post-ischemic recirculation on regional cerebral metabolism and DNA fragmentation was examined in mice subjected to 30 min, 1 h or 2 h transient middle cerebral artery occlusion (MCAO) followed ...
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Chapter and Conference Paper
The Role of Programmed Cell Death in Cerebral Ischemia
Following transient global cerebral ischemia, there is a progressive increase in nitric oxide (NO) synthase activity in hippocampal CA1 neurons that may be enhanced by a lack of protein inhibitor of neuronal N...
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Article
The characteristics of blood-brain barrier in three different conditions — infarction, selective neuronal death and selective loss of presynaptic terminals — following cerebral ischemia
We investigated the extravasation of serum albumin using immunohistochemistry in three different conditions, i.e., infarction, selective neuronal death and selective loss of presynaptic terminals following cer...
