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Article
Therapeutisch induzierte Arteriogenese im Gehirn
Der Schlaganfall ist in den westlichen Industrieländern die dritthäufigste Todesursache und die häufigste Ursache einer bleibenden Pflegebedürftigkeit. Er beruht auf einer zerebralen Minderperfusion, meist in ...
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Chapter and Conference Paper
Slow Progression of Neurologic Impairment after Mild Ischemic Insult in Rodents: Relationship to Metabolic and Histologic Changes
We assessed the relationship between slowly progressing neurologic impairment and metabolic and morphologic changes in two rodent models of mild cerebral ischemia. Mild ischemia was induced by occluding the co...
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Chapter and Conference Paper
Transgenic Mutants for the Investigation of Molecular Stroke Mechanisms
Brain damage induced by focal interruption of blood flow can be differentiated in two pathophysiologically different categories: a hemodynamic type of injury, resulting in primary necrotic brain damage, and a ...
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Chapter and Conference Paper
Relationship Between DNA Fragmentation, Energy State, and Protein Synthesis After Transient Focal Cerebral Ischemia in Mice
The effects of post-ischemic recirculation on regional cerebral metabolism and DNA fragmentation was examined in mice subjected to 30 min, 1 h or 2 h transient middle cerebral artery occlusion (MCAO) followed ...
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Chapter and Conference Paper
Evolution of Energy Failure after Repeated Cerebral Ischemia in Gerbils
We have examined the regional differences in the evolution of energy failure in experimental focal cerebral ischemia. In gerbil brain subjected to repeated unilateral common carotid artery occlusion, the tissu...
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Chapter and Conference Paper
Mitochondrial Dysfunction and Maturation Phenomenon in Ischemic Gerbil Cortex
We examined the time course of energy impairment in the cerebral cortex, which develops cerebral infarction after repeated ischemia. Cerebral ischemia was induced in the gerbil by repeated unilateral carotid-a...
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Chapter and Conference Paper
Metabolic Disturbances and Gene Responses Following Cortical Injury in Rats: Relationship to Spreading Depression
The effects of a cortex lesion on alterations in cortical direct-current (DC) potential, cerebral metabolism and gene expression were examined in rats at 1–6 h after transcranial cold injury. In 14 of 21 injur...
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Article
Effect of global system for mobile communication (GSM) microwave exposure on blood-brain barrier permeability in rat
We investigated the effects of global system for mobile communication (GSM) microwave exposure on the permeability of the blood-brain barrier using a calibrated microwave exposure system in the 900 MHz band. ...
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Chapter and Conference Paper
Modulation of Protein Synthesis and Calcium Uptake Following Traumatic Lesion of Rat Brain Cortex
Following cold lesion of rat brain cortex, the time course of regional cerebral protein synthesis (CSP) and cerebral calcium uptake (CCU) was assessed in the same animal using [3H]leucine and 45CaCl by means of d...
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Chapter and Conference Paper
Insight into the Protective Mechanisms of Cortical Spreading Depression in Cardiac Arrest Cerebral Ischemia in Rat
Cortical spreading depression has recently been shown to protect hippocampal CA1 pyramidal neurons, as well as cortical neurons, against ischemic damage if elicited prior to ischemia. The present study was und...
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Article
Relationship between blood flow and blood-brain barrier permeability of sodium and albumin in focal ischaemia of rats: A triple tracer autoradiographic study
Local cerebral blood flow, the permeability of the blood-brain barrier to sodium and serum albumin, and the content of electrolytes were investigated in rats before and at 4 h and 24 h following permanent occl...
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Chapter
Autoradiographic and Biochemical Imaging in Cerebral Ischemia
The central nervous system consists of innumerable anatomical subunits, each of which participate in one or several functional activities during the normal state of the brain. The maintenance of cerebral activ...
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Chapter and Conference Paper
Possible Role of Intracellular Calcium Translocation in the Maturation of Ischemic Damage
The fine structural localization of calcium was studied in 3-month-old female Mongolian gerbils (Meriones unguiculatus) subjected to single 5-min bilateral common carotid artery occlusions. Intracellular calcium ...
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Chapter and Conference Paper
Protein Synthesis and Calcium Uptake Following Complete Cerebral Ischemia of Rat Brain
The possible involvement of neuroexcitatory pathomechanisms in the development of postischemic neuron injury was examined in rats subjected to 10-min cardiac arrest for the induction of complete cerebral ische...
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Article
Relationship between of blood flow, glucose metabolism, protein synthesis, glucose and ATP content in experimentally-induced glioma (RG12.2) of rat brain
In experimental RGl 2.2 glioma of rat brain, local blood flow, glucose utilization, protein synthesis, glucose and ATP content were measured by means of triple tracer autoradiography and bioluminescence techni...
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Chapter and Conference Paper
Role of Neuroexcitation in Development of Blood-Brain Barrier and Oedematous Changes Following Cerebral Ischaemia and Traumatic Brain Injury
Potential involvement of neuroexcitatory mechanisms was studied in: 1) repetitive forebrain ischaemia in gerbils, 2) global cerebral ischaemia in rats and 3) cryogenic injury to the cerebral cortex in rats and...
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Article
Blood flow and metabolism in heterotopic cerebellar grafts during hypoglycemia
Hypoglycemia-induced disturbances of brain metabolism and neuronal injury exhibit a distinct predilection for forebrain structures, in particular the caudate-putamen, hippocampus and cerebral cortex, whereas t...
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Article
Regional profile of polyamines in reversible cerebral ischemia of Mongolian gerbils
Reversible cerebral ischemia was produced in Mongolian gerbils (Meriones unguicultatus) by occluding both common carotid arteries. After 5 min ischemia brains were recirculated, for 8, 24, 48, 72, or 96 h. An add...
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Chapter and Conference Paper
Regional Hemodynamic and Metabolic Disturbances in Experimental Cerebral Ischemia
Measurements of regional blood flow and metabolism have proved to be of considerable interest for evaluating the size and severity of tissue damage following stroke. Therefore, various clinical imaging techniq...
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Chapter
Neuropathology and Regional Imaging of Microcirculation, Tissue pH, Metabolites and Necroses in Cerebral RG2 and F98 Anaplastic Rat Glioma Transplantation Tumors
Malignant human gliomas corresponding to grade III and IV are anaplastic ependymomas, anaplastic astrocytomas, anaplastic oligodendrogliomas, anaplastic mixed gliomas and the glioblastoma group (WHO classifica...
