12 Result(s)
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Patrick L. Sutton
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Open AccessThe Plasmodium falciparum merozoite surface protein-1 19 KD antibody response in the Peruvian Amazon predominantly targets the non-allele specific, shared sites of this antigen
Plasmodium falciparum re-emerged in Iquitos, Peru in 1994 and is now hypoendemic (< 0.5 infections/person/year). Purportedly non-immune individuals with discrete (non-overlap**) P. falciparum infections can be ...
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Open AccessSexual recombination is a signature of a persisting malaria epidemic in Peru
The aim of this study was to consider the impact that multi-clone, complex infections have on a parasite population structure in a low transmission setting. In general, complexity of infection (minimum number ...
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Open AccessMutant pfcrt "SVMNT" haplotype and wild type pfmdr1 "N86" are endemic in Plasmodium vivax dominated areas of India under high chloroquine exposure
Chloroquine resistance (CQR) phenotype in Plasmodium falciparum is associated with mutations in pfcrt and pfmdr-1 genes. Mutations at amino acid position 72-76 of pfcrt gene, here defined as pfcrt haplotype are a...
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Open AccessThe complexities of malaria disease manifestations with a focus on asymptomatic malaria
Malaria is a serious parasitic disease in the develo** world, causing high morbidity and mortality. The pathogenesis of malaria is complex, and the clinical presentation of disease ranges from severe and com...
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The malaria parasite Plasmodium vivax exhibits greater genetic diversity than Plasmodium falciparum
Jane Carlton and colleagues report the genome sequencing, de novo assembly and annotation of four Plasmodium vivax reference strains from diverse geographic locations. Their cross-species comparisons show that P....
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Open AccessPlasmodium cynomolgi genome sequences provide insight into Plasmodium vivax and the monkey malaria clade
Jane Carlton, Kazuyuki Tanabe and colleagues report the draft genome sequences of three Plasmodium cynomolgi strains isolated from infected monkeys. Their comparative genomic analysis with P. vivax and P. knowles...
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Open AccessA call to arms: on refining Plasmodium vivax microsatellite marker panels for comparing global diversity
Microsatellite (MS) markers have become an important tool for studying the population diversity, evolutionary history and multiplicity of infection (MOI) of malaria parasite infections. MS are typically select...
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Open AccessChloroquine efficacy studies confirm drug susceptibility of Plasmodium vivax in Chennai, India
Assessing the Plasmodium vivax burden in India is complicated by the potential threat of an emerging chloroquine (CQ) resistant parasite population from neighbouring countries in Southeast Asia. Chennai, the capi...
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Open AccessWhat is the value of reactive case detection in malaria control? A case-study in India and a systematic review
Reactive case detection (RCD) for malaria is a strategy to identify additional malaria infections in areas of low malaria transmission and can complement passive surveillance. This study describes experiences ...
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Open AccessThe use of mosquito repellents at three sites in India with declining malaria transmission: surveys in the community and clinic
Repellents such as coils, vaporizers, mats and creams can be used to reduce the risk of malaria and other infectious diseases. Although evidence for their effectiveness is limited, they are advertised as provi...
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Population genomics studies identify signatures of global dispersal and drug resistance in Plasmodium vivax
Jane Carlton, Daniel Neafsey and colleagues report a population genomics analysis of 182 Plasmodium vivax isolates from 11 countries. They find evidence of regional adaptation and signatures of selection at genes...
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Open AccessThe burden of submicroscopic and asymptomatic malaria in India revealed from epidemiology studies at three varied transmission sites in India
Malaria in India, while decreasing, remains a serious public health problem, and the contribution of submicroscopic and asymptomatic infections to its persistence is poorly understood. We conducted community s...
