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Home chemical and microbial transitions across urbanization
Urbanization represents a profound shift in human behaviour, and has considerable cultural and health-associated consequences1,2. Here, we investigate chemical and microbial characteristics of houses and their hu...
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Open AccessSexual recombination is a signature of a persisting malaria epidemic in Peru
The aim of this study was to consider the impact that multi-clone, complex infections have on a parasite population structure in a low transmission setting. In general, complexity of infection (minimum number ...
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Article
Open AccessLimited variation in vaccine candidate Plasmodium falciparum Merozoite Surface Protein-6 over multiple transmission seasons
Plasmodium falciparum Merozoite Surface Protein-6 (PfMSP6) is a component of the complex proteinacious coat that surrounds P. falciparum merozoites. This location, and the presence of anti-PfMSP6 antibodies in P....
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Open AccessThe Plasmodium falciparum merozoite surface protein-1 19 KD antibody response in the Peruvian Amazon predominantly targets the non-allele specific, shared sites of this antigen
Plasmodium falciparum re-emerged in Iquitos, Peru in 1994 and is now hypoendemic (< 0.5 infections/person/year). Purportedly non-immune individuals with discrete (non-overlap**) P. falciparum infections can be ...
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Open AccessAntibody response dynamics to the Plasmodium falciparum conserved vaccine candidate antigen, merozoite surface protein-1 C-terminal 19kD (MSP1-19kD), in Peruvians exposed to hypoendemic malaria transmission
In high-transmission areas, develo** immunity to symptomatic Plasmodium falciparum infections requires 2–10 years of uninterrupted exposure. Delayed malaria-immunity has been attributed to difficult-to-develop ...
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Open AccessGenetic diversity of vaccine candidate antigens in Plasmodium falciparum isolates from the Amazon basin of Peru
Several of the intended Plasmodium falciparum vaccine candidate antigens are highly polymorphic and could render a vaccine ineffective if their antigenic sites were not represented in the vaccine. In this study, ...
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Correction: Chromosome-wide SNPs reveal an ancient origin for Plasmodium falciparum
Nature 418, 323–326 (2002). It has been drawn to our attention that the 3D7 parasite, labelled as an African parasite in our Letter, was initially isolated from The Netherlands, although we have some genetic e...
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Chromosome-wide SNPs reveal an ancient origin for Plasmodium falciparum
The Malaria's Eve hypothesis, proposing a severe recent population bottleneck (about 3,000–5,000 years ago) of the human malaria parasite Plasmodium falciparum, has prompted a debate about the origin and evolutio...
