56 Result(s)

Article

Colorectal cancer and advanced adenoma characteristics according to causative mismatch repair gene variant in Japanese colorectal surveillance for Lynch syndrome

The optimal interval of colonoscopy (CS) surveillance in cases with Lynch syndrome (LS), and stratification according to the causative mismatch repair gene mutation, has received much attention. To verify a fe...

Akiko Chino, Kohji Tanakaya, Takeshi Nakajima, Kiwamu Akagi… in Journal of Gastroenterology (2024)

Article

Marital status after colorectal surgery in familial adenomatous polyposis: a nationwide multicenter study in Japan

Patients with familial adenomatous polyposis (FAP) experience psychological and social challenges concerning future events such as marriage and childbirth alongside the medical risks of colorectal cancer (CRC)...

Kenji Fujiyoshi, Tomoya Sudo, Fumihiko Fujita… in International Journal of Clinical Oncology (2024)

Article

Clinical features and distribution of the APC variant in duodenal and ampullary polyps in patients with familial adenomatous polyposis: a multicenter retrospective cohort study in Japan

Management of duodenal or ampullary adenomas in patients with familial adenomatous polyposis (FAP) is a major challenge for clinicians. Insufficient data are available to evaluate the clinical manifestations a...

Yasuyuki Miyakura, Tatsuro Yamaguchi… in International Journal of Clinical Oncology (2024)

Article

Risk of metachronous colorectal cancer after colectomy for first colon cancer in Lynch syndrome: multicenter retrospective study in Japan

We evaluated the risk of metachronous colorectal cancer (mCRC) and explored the optimal extent of colectomy in patients with Lynch syndrome (LS) and first colon cancer (fCC) in Japan, where the extent of colec...

Kenichi Chikatani, Hideyuki Ishida… in International Journal of Clinical Oncology (2023)

Article

Risk of first onset of colorectal cancer associated with alcohol consumption in Lynch syndrome: a multicenter cohort study

Complex interactions among endogenous and exogenous factors influence the incidence of colorectal cancer (CRC). Germline mutations in mismatch repair (MMR) genes causing Lynch syndrome (LS) are major endogenou...

Kenji Fujiyoshi, Tomoya Sudo, Fumihiko Fujita… in International Journal of Clinical Oncology (2022)

Article

APC germline variant analysis in the adenomatous polyposis phenotype in Japanese patients

Familial adenomatous polyposis (FAP), an autosomal dominant disorder characterized by multiple colonic polyps, is caused by a germline pathogenic variant of the APC gene. However, this variant is not detected in ...

Misato Takao, Tatsuro Yamaguchi… in International Journal of Clinical Oncology (2021)

Article

Evaluation of FOLFOX or CAPOX reintroduction with or without bevacizumab in relapsed colorectal cancer patients treated with oxaliplatin as adjuvant chemotherapy (REACT study)

Chemotherapy in relapsed colorectal cancer patients treated with oxaliplatin as adjuvant chemotherapy is under debate. REACT study aimed to investigate the efficacy of reintroducing modified FOLFOX6 (mFOLFOX6)...

Masahito Kotaka, Shigeyoshi Iwamoto… in International Journal of Clinical Oncology (2020)

Article

Phase II study of S-1-based sequential combination chemotherapy including oxaliplatin plus bevacizumab and irinotecan with or without cetuximab for metastatic colorectal cancer: the SOBIC trial

Fluorouracil and leucovorin combined with oxaliplatin or irinotecan plus bevacizumab (Bmab) or cetuximab (Cmab) are now widely accepted treatment options as first-line or second-line chemotherapy for metastati...

Yoshihiko Nakamoto, Masafumi Noda… in International Journal of Clinical Oncology (2020)

Article

Introduction: Lynch syndrome—its molecular mechanism and current topics

Naohiro Tomita in International Journal of Clinical Oncology (2019)

Article

Prevalence of and risk factors for thyroid carcinoma in patients with familial adenomatous polyposis: results of a multicenter study in Japan and a systematic review

To investigate the recent Japanese prevalence of thyroid cancer and its characteristics in familial adenomatous polyposis (FAP) patients, through the development of surveillance programs.

Haruki Sada, Takao Hinoi, Hideki Ueno, Tatsuro Yamaguchi, Yasuhiro Inoue… in Surgery Today (2019)

Article

Alcohol consumption and early-onset risk of colorectal cancer in Japanese patients with Lynch syndrome: a cross-sectional study conducted by the Japanese Society for Cancer of the Colon and Rectum

We conducted this study to establish whether drinking alcohol alters the risk of early-onset colorectal cancer (CRC) in Japanese patients with Lynch syndrome (LS). The subjects were 66 LS patients with pathoge...

Masashi Miguchi, Takao Hinoi, Kohji Tanakaya, Tatsuro Yamaguchi… in Surgery Today (2018)

Article

The treatment of desmoid tumors associated with familial adenomatous polyposis: the results of a Japanese multicenter observational study

Familial adenomatous polyposis (FAP)-associated desmoid tumor (DT) is sometimes life threatening. However, the optimal treatment for DTs has not been established. The aim of this study was to analyze the outco...

Yasuhiro Inoue, Hideyuki Ishida, Hideki Ueno, Hirotoshi Kobayashi… in Surgery Today (2017)