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  1. No Access

    Article

    Systems-level effects of allosteric perturbations to a model molecular switch

    Molecular switch proteins whose cycling between states is controlled by opposing regulators1,2 are central to biological signal transduction. As switch proteins function within highly connected interaction networ...

    Tina Perica, Christopher J. P. Mathy, Jiewei Xu, Gwendolyn Μ. Jang, Yang Zhang… in Nature (2021)

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    Article

    A 31-residue peptide induces aggregation of tau's microtubule-binding region in cells

    The self-propagation of misfolded conformations of tau underlies neurodegenerative diseases, including Alzheimer's. There is considerable interest in discovering the minimal sequence and active conformational ...

    Jan Stöhr, Haifan Wu, Mimi Nick, Yibing Wu, Manasi Bhate… in Nature Chemistry (2017)

  3. No Access

    Article

    Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism

    The retinoblastoma binding protein KDM5A removes methyl marks from lysine 4 of histone H3 (H3K4). Misregulation of KDM5A contributes to the pathogenesis of lung and gastric cancers. In addition to its catalyti...

    Idelisse Ortiz Torres, Kristopher M. Kuchenbecker, Chimno I. Nnadi… in Nature Communications (2015)

  4. Article

    Open Access

    1H nuclear magnetic resonance brain metabolomics in neonatal mice after hypoxia–ischemia distinguished normothermic recovery from mild hypothermia recoveries

    Mild brain hypothermia (31–34 °C) after neonatal hypoxia–ischemia (HI) improves neurodevelopmental outcomes in human and animal neonates. Using an asphyxia model with neonatal mice treated with mild hypothermi...

    Jia Liu, R. Ann Sheldon, Mark R. Segal, Mark J.S. Kelly… in Pediatric Research (2013)

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    Article

    The structural basis of yeast prion strain variants

    A comprehensive structural analysis of the complete and unmodified Sup35 prion domain in two distinct infectious conformations is presented. A variety of techniques is used to provide structural details of the...

    Brandon H. Toyama, Mark J. S. Kelly, John D. Gross, Jonathan S. Weissman in Nature (2007)

  6. No Access

    Article

    Application of amino acid type-specific 1H- and 14N-labeling in a 2H-, 15N-labeled background to a 47 kDa homodimer: Potential for NMR structure determination of large proteins

    NMR investigations of larger macromolecules (>20 kDa) are severely hindered by rapid 1H and 13C transverse relaxation. Replacement of non-exchangeable protons with deuterium removes many efficient 1H-1H and 1H...

    Mark J.S. Kelly, Cornelia Krieger, Linda J. Ball, Yihua Yu… in Journal of Biomolecular NMR (1999)