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    Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism

    The retinoblastoma binding protein KDM5A removes methyl marks from lysine 4 of histone H3 (H3K4). Misregulation of KDM5A contributes to the pathogenesis of lung and gastric cancers. In addition to its catalyti...

    Idelisse Ortiz Torres, Kristopher M. Kuchenbecker, Chimno I. Nnadi… in Nature Communications (2015)