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  1. No Access

    Article

    A chaperone-like function of FUS ensures TAZ condensate dynamics and transcriptional activation

    The Hippo pathway has important roles in organ development, tissue homeostasis and tumour growth. Its downstream effector TAZ is a transcriptional coactivator that promotes target gene expression through the f...

    Yangqing Shao, **n Shu, Yi Lu, Wenxuan Zhu, Ran Li, Huanyi Fu… in Nature Cell Biology (2024)

  2. No Access

    Article

    A 31-residue peptide induces aggregation of tau's microtubule-binding region in cells

    The self-propagation of misfolded conformations of tau underlies neurodegenerative diseases, including Alzheimer's. There is considerable interest in discovering the minimal sequence and active conformational ...

    Jan Stöhr, Haifan Wu, Mimi Nick, Yibing Wu, Manasi Bhate… in Nature Chemistry (2017)

  3. No Access

    Chapter

    Engineering AApeptides for Translational Medicine

    Peptidomimetics, designed to mimic the structure and function of bioactive peptides, have found enormous application in the development of translational medicine. The emergence of novel peptidomimetics will co...

    Haifan Wu, Jianfeng Cai in Engineering in Translational Medicine (2014)

  4. No Access

    Protocol

    Synthesis of AApeptides

    The creation and development of nonnatural peptidomimetics has become an area of increasing significance in bioorganic and chemical biology. A wide range of new peptide mimics with novel structures and functio...

    Youhong Niu, Yaogang Hu, Haifan Wu… in Peptide Modifications to Increase Metaboli… (2013)