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Article
Open AccessDe novo-designed transmembrane proteins bind and regulate a cytokine receptor
Transmembrane (TM) domains as simple as a single span can perform complex biological functions using entirely lipid-embedded chemical features. Computational design has the potential to generate custom tool mo...
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Article
Open AccessA grooved conduit combined with decellularized tissues for peripheral nerve regeneration
Peripheral nerve injury (PNI) is a common and severe clinical disease worldwide, which leads to a poor prognosis because of the complicated treatments and high morbidity. Autologous nerve grafting as the gold ...
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Article
Microsurgical Knotting Technique for Vascular Anastomosis
To introduce a new knotting technique for vascular anastomosis, which was different from the conventional knotting methods, is the aim of this study. A microsurgeon learned this technique and practiced on gauz...
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Chapter and Conference Paper
Identifying Key Factors Influencing Mobile Music App User Experience in China Using a Fuzzy DEMATEL Method
The main purpose of this paper is to construct the evaluation index of the system and study the degree of influence of the main factors affecting the design of mobile music app from the perspective of user exp...
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Article
Open AccessSuperabsorbent hydrogels enhanced by quaternized tunicate cellulose nanocrystals with adjustable strength and swelling ratio
Superabsorbent hydrogels were prepared from biodegradable material, where the matrix was cross-linked cellulose and carboxymethyl cellulose and reinforced by quaternized tunicate cellulose nanocrystals (Q-TCNC...
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Chapter and Conference Paper
Research on Service Design of Balanced Vehicle Based on Kansei Engineering
With improvement of people’s consumption level and the comprehensive promotion of the concept of low-carbon globalization, people’s demand for balanced vehicle has been upgraded from a single transportation fu...
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Chapter and Conference Paper
Optimal Design of Rescue Motor Boat Based on Ergonomics
With the continuous advancement of technology and materials and the continuous changes in demand, the design of vehicles has gradually changed from machine-oriented to human-oriented, and the goal of the desig...
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Chapter and Conference Paper
Research on Longquan Celadon Cultural and Creative Products Based on Kansei Engineering
With the development of the tourism industry, the cultural and creative products of tourism have shifted to diversified products, and its development plays a vital role in the prosperity of regional economy, ...
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Chapter and Conference Paper
A Study of the Impact of Changes in Software Interface Design Elements on Visual Fatigue
With the advent of the paperless era, electronic working devices have become the norm, and people are increasingly relying on software in mobile phones and computers to process their work. Long hours of readin...
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Chapter and Conference Paper
Design of Sustainable Food Management System Based on User’s Whole Behavior Process
Food waste is a persistent global problem with negative economic, environmental, and social impacts. Consumers are one of the main sources of food waste. Many scholars have studied consumer behavior, but relat...
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Article
Efficacy of Large Groove Texture on Rat Sciatic Nerve Regeneration In Vivo Using Polyacrylonitrile Nerve Conduits
Physical guidance cues play an important role in enhancing the efficiency of nerve conduits for peripheral nerve injury repair. However, very few in vivo investigations have been performed to evaluate the repair ...
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Article
Phenolic Components of the Aerial Parts of Achillea alpina
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Article
Graft bending angle affects allograft tendon maturity early after anterior cruciate ligament reconstruction
The aim of this study was to clarify the association of the anterior cruciate ligament (ACL) graft bending angle and graft maturity of autograft and allograft tendons using high-resolution MRI.
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Article
Correlation between oxygen vacancies and room-temperature ferromagnetism in Ti0.94Co0.03La0.03O2 nanoparticles influenced by different post annealing treatment
The correlation between oxygen vacancies and room-temperature ferromagnetism in Ti0.94Co0.03La0.03O2 nanoparticles is investigated by treating the samples in different post annealing process. Ti0.94Co0.03La0.03O2
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Article
De novo design of a hyperstable non-natural protein–ligand complex with sub-Å accuracy
Protein catalysis requires the atomic-level orchestration of side chains, substrates and cofactors, and yet the ability to design a small-molecule-binding protein entirely from first principles with a precisel...
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Article
New Thiophene Acetylene from Echinops spinosissimus subsp. spinosus
A new thiophene acetylene, named 2,2-dimethyl-4-[5′-(prop-1-ynyl)-2,2′-bithiophen-5-yl]-1,3-dioxolane (1), was isolated from the roots of Echinops spinosus, and the structure was elucidated on the basis of oneand...
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Article
Granaxylocartin A, New Limonoid from the Seeds of Xylocarpus granatum
A new limonoid, named granaxylocartin A (1), was isolated from the seeds of Xylocarpus granatum, and the structure was elucidated on the basis of one- and two-dimensional NMR (including 1H, 13C NMR, DEPT, 1H–1H C...
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Article
A 31-residue peptide induces aggregation of tau's microtubule-binding region in cells
The self-propagation of misfolded conformations of tau underlies neurodegenerative diseases, including Alzheimer's. There is considerable interest in discovering the minimal sequence and active conformational ...
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Article
A chemometric-assisted LC–MS/MS method for the simultaneous determination of 17 limonoids from different parts of Xylocarpus granatum fruit
The marine mangrove Xylocarpus granatum is used as a folk medicine and is rich in bioactive limonoids. The quantitative determination of the chemical composition and distribution of limonoids in different parts o...
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Article
Designed metalloprotein stabilizes a semiquinone radical
Enzymes use binding energy to stabilize their substrates in high-energy states that are otherwise inaccessible at ambient temperature. Here we show that a de novo designed Zn(II) metalloprotein stabilizes a chemi...
