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  1. No Access

    Article

    Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism

    The retinoblastoma binding protein KDM5A removes methyl marks from lysine 4 of histone H3 (H3K4). Misregulation of KDM5A contributes to the pathogenesis of lung and gastric cancers. In addition to its catalyti...

    Idelisse Ortiz Torres, Kristopher M. Kuchenbecker, Chimno I. Nnadi… in Nature Communications (2015)

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    Article

    The glucocorticoid receptor dimer interface allosterically transmits sequence-specific DNA signals

    Glucocorticoid receptor (GR) binds as a dimer to DNA, with the canonical binding sequence featuring two half-sites, each bound by one monomer, separated by a 3-bp spacer. The specific bases contacted by GR are...

    Lisa C Watson, Kristopher M Kuchenbecker… in Nature Structural & Molecular Biology (2013)