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Open AccessTranscriptomics and metabolomics reveal hypothalamic metabolic characteristics and key genes after subarachnoid hemorrhage in rats
Subarachnoid hemorrhage (SAH) is a serious hemorrhagic event with high mortality and morbidity. Multiple injurious events produced by SAH can lead to a series of pathophysiologic processes in the hypothalamus ...
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Article
Correction to: MAP2K6 remodels chromatin and facilitates reprogramming by activating Gatad2b-phosphorylation dependent heterochromatin loosening
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Homologous Expression and Characterization of α-L-rhamnosidase from Aspergillus niger for the Transformation of Flavonoids
Aspergillus niger has been used for homologous and heterologous expressions of many protein products. In this study, the α-L-rhamnosidase from A. niger (Rha-N1, GenBank XP_001389086.1) was homologously expressed ...
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Article
MAP2K6 remodels chromatin and facilitates reprogramming by activating Gatad2b-phosphorylation dependent heterochromatin loosening
Somatic cell reprogramming is an ideal model for studying epigenetic regulation as it undergoes dramatic chromatin remodeling. However, a role for phosphorylation signaling in chromatin protein modifications f...
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Article
Correction to: Quantification and toxicokinetics of paraquat in mouse plasma and lung tissues by internal standard surface enhanced Raman spectroscopy
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Quantification and toxicokinetics of paraquat in mouse plasma and lung tissues by internal standard surface-enhanced Raman spectroscopy
Paraquat is a quaternary ammonium herbicide with an excellent herbicidal effect but is highly toxic to human and animals. Although prohibited by many countries, paraquat intoxication occurred occasionally and ...
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Article
Effect of Coformer Selection on In Vitro and In Vivo Performance of Adefovir Dipivoxil Cocrystals
This study aimed to improve the in vitro dissolution, permeability and oral bioavailability of adefovir dipivoxil (ADD) by cocrystal technology and clarify the important role of coformer selection on the cocrysta...
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Article
Open AccessSRSF1 promotes the inclusion of exon 3 of SRA1 and the invasion of hepatocellular carcinoma cells by interacting with exon 3 of SRA1pre-mRNA
Steroid receptor RNA activator 1 (SRA1) has been described as a novel transcriptional co-activator that affects the migration of cancer cells. Through RT-PCR, we identified that skip** exon 3 of SRA1 produces t...
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Engineering the regulatory site of the catalase promoter for improved heterologous protein production in Pichia pastoris
To build a stronger Pichia pastoris PCAT1 promoter and to identify putative transcriptional factor binding sites (TFBSs) on PCAT1 that affect the activity of the promoter.
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Article
Hydrogel-based microbeads for Raman-encoded suspension array using the reversed-phase suspension polymerization method and ultraviolet light curing
A one-step synthesis using the reversed-phase suspension polymerization method and ultraviolet light curing is proposed for preparing the Raman-encoded suspension array (SA). The encoded microcarriers are prep...
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Article
Open AccessCircular RNA hsa_circ_001783 regulates breast cancer progression via sponging miR-200c-3p
Increasing evidence suggests circular RNAs (circRNAs) exert critical functions in tumor progression via sponging miRNAs (microRNAs). However, the role of circRNAs in breast cancer remains unclear. Here we syst...
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Open AccessSFRP2 enhances the osteogenic differentiation of apical papilla stem cells by antagonizing the canonical WNT pathway
Exploring the molecular mechanisms underlying directed differentiation is helpful in the development of clinical applications of mesenchymal stem cells (MSCs). Our previous study on dental tissue-derived MSCs ...
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Diachronic analysis of genetic diversity in rice landraces under on-farm conservation in Yunnan, China
Diachronic analysis showed no significant changes in the level of genetic diversity occurred over the past 27 years’ domestication, which indicated genetic diversity was successfully maintained...
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A recombinant trans-membrane protein hMnSOD–R9 inhibits the proliferation of cervical cancer cells in vitro
Human manganese superoxide dismutase (hMnSOD) is a new type of cancer suppressor. Nonamer of arginine (R9) is an efficient protein transduction domain (PTD). The aim of the study was to improve the transductio...
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The First Tian** Forum on Tumor Microenvironment Tian**, China, July 2–4, 2010
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Cloning and expression of a luxRhomologue from Xanthomonas oryzae pv. oryzae
LuxR homologues are the main components of LuxR/LuxI circuit in Quorum Sensing (QS) of Gram-negative bacteria. A luxR homologue, designated as xooR, was cloned from X. oryzae pv. oryzae. The xooR gene is a trans...