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Article
Unsupervised stain augmentation enhanced glomerular instance segmentation on pathology images
In pathology images, different stains highlight different glomerular structures, so a supervised deep learning-based glomerular instance segmentation model trained on individual stains performs poorly on other...
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Article
Open AccessTEC-miTarget: enhancing microRNA target prediction based on deep learning of ribonucleic acid sequences
MicroRNAs play a critical role in regulating gene expression by binding to specific target sites within gene transcripts, making the identification of microRNA targets a prominent focus of research. Convention...
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Chapter and Conference Paper
Classification of Myopic Maculopathy Images with Self-supervised Driven Multiple Instance Learning Network
Myopia is a high-incidence disease that widely exists across various regions. If left unaddressed, it may escalate into high myopia. The leading cause of visual impairment is myopic maculopathy. Currently, cer...
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Chapter and Conference Paper
ADEQ: Adaptive Diversity Enhancement for Zero-Shot Quantization
Zero-shot quantization (ZSQ) is an effective way to compress neural networks, especially when real training sets are inaccessible because of privacy and security issues. Most existing synthetic-data-driven zer...
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Article
Unsupervised domain adaptive tumor region recognition for Ki67 automated assisted quantification
Ki67 is a protein associated with tumor proliferation and metastasis in breast cancer and acts as an essential prognostic factor. Clinical work requires recognizing tumor regions on Ki67-stained whole-slide im...
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Article
Open AccessUnique DUOX2+ACE2+ small cholangiocytes are pathogenic targets for primary biliary cholangitis
Cholangiocytes play a crucial role in bile formation. Cholangiocyte injury causes cholestasis, including primary biliary cholangitis (PBC). However, the etiology of PBC remains unclear despite being characteri...
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Chapter and Conference Paper
IIB-MIL: Integrated Instance-Level and Bag-Level Multiple Instances Learning with Label Disambiguation for Pathological Image Analysis
Digital pathology plays a pivotal role in the diagnosis and interpretation of diseases and has drawn increasing attention in modern healthcare. Due to the huge gigapixel-level size and diverse nature of whole-...
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Chapter and Conference Paper
DEST: Deep Enhanced Swin Transformer Toward Better Scoring for NAFLD
Nonalcoholic fatty liver disease (NAFLD) has become one of the most common liver diseases. Image analysis of liver biopsy is the gold standard for early diagnosis of NAFLD. Deep learning offers an effective to...
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Chapter and Conference Paper
The Generation of Virtual Immunohistochemical Staining Images Based on an Improved Cycle-GAN
Pathological examination is the gold standard for the diagnosis of cancer. In general, common pathological examinations include hematoxylin-eosin (H&E) staining and immunohistochemistry. H&E staining examinati...
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Article
Hydrogel-based microbeads for Raman-encoded suspension array using the reversed-phase suspension polymerization method and ultraviolet light curing
A one-step synthesis using the reversed-phase suspension polymerization method and ultraviolet light curing is proposed for preparing the Raman-encoded suspension array (SA). The encoded microcarriers are prep...
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Article
Open AccessIn situ map** of activity distribution and oxygen evolution reaction in vanadium flow batteries
Understanding spatial distribution difference and reaction kinetics of the electrode is vital for enhancing the electrochemical reaction efficiency. Here, we report a total internal reflection imaging sensor w...
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Article
Gold-nanorod-enhanced Raman spectroscopy encoded micro-quartz pieces for the multiplex detection of biomolecules
The rapid analysis and detection of biomolecules has become increasingly important in biological research. Hence, here we propose a novel suspension array method that is based on gold nanorod (AuNR)-enhanced R...
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Article
Open AccessLabel-free and Non-destruction Determination of Single- and Double-Strand DNA based on Quantum Weak Measurement
The process of unwinding and renaturation of DNA has been widely used in studies of nucleotide sequence organization. Compared with traditional methods for DNA unwinding and renaturation, the label-free and no...
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Article
A Waveguide-Coupled Surface Plasmon Resonance Sensor Using an Au-MgF2-Au Structure
We describe an Au-MgF2-Au trilayered waveguide-coupled surface plasmon resonance (WCSPR) sensor in this article. The characteristics of this sensing structure are compared with those of the conventional single-la...
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Chapter and Conference Paper
DPANet: A Novel Network Based on Dense Pyramid Feature Extractor and Dual Correlation Analysis Attention Modules for Colon Glands Segmentation
Accurate segmentation of glands from histology images is a crucial step to obtain reliable morphological statistics for quantitative diagnosis. However, this task is formidable because of the enormous variabi...
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Article
Digital triplex DNA assay based on plasmonic nanocrystals
A new analytical method has been developed to detect three kinds of DNA simultaneously based on magnetic beads and color-encoded plasmonic nanocrystals. Magnetic beads modified with capture DNA are employed to...
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Article
Open AccessDigital barcodes of suspension array using laser induced breakdown spectroscopy
We show a coding method of suspension array based on the laser induced breakdown spectroscopy (LIBS), which promotes the barcodes from analog to digital. As the foundation of digital optical barcodes, nanocrys...
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Article
The detection method for small molecules coupled with a molecularly imprinted polymer/quantum dot chip using a home-built optical system
A method to detect small molecules with a molecularly imprinted polymer/quantum dot (MIP-QD) chip using a home-built optical fluidic system was first proposed in this study. Ractopamine (RAC) was used as the m...
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Article
Temperature-Regulated Surface Plasmon Resonance Imaging System for Bioaffinity Sensing
We describe a temperature-regulated surface plasmon resonance (SPR) imaging biosensor in this article. The sample temperature can be regulated for specific requirements of the bioaffinity sensing, and stabiliz...
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Article
Core 2 Mucin-Type O-Glycan Is Related to EPEC and EHEC O157:H7 Adherence to Human Colon Carcinoma HT-29 Epithelial Cells
The roles of host glycosylation in interactions with EPEC and EHEC O157:H7 are largely unclear; this study examined whether O-glycans are involved in EPEC and EHEC O157:H7 adherence to HT-29 cells.
