-
Article
Open AccessAbaloparatide-SC improves trabecular microarchitecture as assessed by trabecular bone score (TBS): a 24-week randomized clinical trial
In a phase 2 trial of 222 postmenopausal women with osteoporosis aged 55 to 85 years randomized to one of three different doses of abaloparatide-SC, subcutaneous teriparatide, or placebo for 24 weeks, abalopar...
-
Article
“Orthogonal polarization spectral imaging”Eine neue klinische Methode für das Monitoring der Mikrozirkulation
Mit “orthogonal polarization spectral imaging” (OPS-Imaging) steht ein neues nichtinvasives Untersuchungsverfahren zur Verfügung, das mikrovaskuläre Veränderungen am Menschen für verschiedene Organe direkt sic...
-
Article
Open AccessOrthogonal polarisation spectral imaging as a new tool for the assessment of antivascular tumour treatment in vivo: a validation study
Tumour angiogenesis plays a key role in tumour growth, formation of metastasis, detection and treatment of malignant tumours. Recent investigations provided increasing evidence that quantitative analysis of tu...
-
Article
Implementation of the Microdialysis Method in the Hamster Dorsal Skinfold Chamber
The aim of this study was to implement the microdialysis method, a well-established technique for measuring the local concentration of neurotransmitters and metabolites in the brain, in the dorsal skinfold cha...
-
Article
Solitary Hepatic Infantile Myofibromatosis in a Female Adolescent
-
Article
Pyoderma gangrenosum with hepatopancreatic manifestations in a patient with rheumatoid arthritis
Pyoderma gangrenosum is a dermatological disease of unknown origin. We report the case of a 47-year-old woman with cutaneous lesions of pyoderma gangrenosum associated with hepaticopancreatic involvement. We f...
-
Article
Consensus statement: Octreotide dose titration in secretory diarrhea
Octreotide is an effective therapeutic option in controlling secretory diarrhea of varied etiology. However, marked patient-to-patient differences in the antidiarrheal effects necessitate titration of octreoti...
-
Article
A prospective multicenter octreotide dose response study in the treatment of acromegaly
The somatostatin analog octreotide has proven to be an effective form of treatment for various hypersecretory states including acromegaly. This report describes the effects of escalating doses of octreotide on...
-
Article
Effects of octreotide on biliary lipid composition and occurrence of cholesterol crystals in patients with acromegaly
Treatment with the somatostatin analog octreotide is associated with increased gallstone formation. The mechanism of formation of these stones is unclear. The purpose of this study was to examine the effect of...
-
Article
Clinical use of the long acting somatostatin analogue octreotide in pediatrics
Preliminary data of the use of the long-acting somatostatin analog octreotide (Sandostatin) in pediatrics are reported. In nesidioblastosis and other hyperinsulinemic conditions, timely treatment with octreoti...
-
Article
Gallstones in acromegalic patients undergoing different treatment regimens
The frequency of gallstones during longterm treatment with the somatostatin analogue octreotide reported in different studies varies from 0% to 50%, the reason for this variation being unknown. Therefore, we e...
-
Article
Reduction in sella turcica volume
Ten patients with acromegaly were treated with the long-acting somatostatin analogue, Sandostatin (SMS 201-995, octreotide) for more than one year. Computerized tomography was performed before and on 4 differe...
-
Article
LONG TERM TREATMENT BY A LONG ACTING SOMATOSTATIN ANALOGUE (SMS 201–995) IN A 4 MONTHS BOY PRESENTING WITH PRIMARY PERMANENT HYPERINSULINISM
SMS 201-995 was used in a 4 month-old boy presenting hypoglycemic seizures with hyperinsulinism. The dose of SMS 201-995 was rapidly increased during the first week from 10 ug/kg/day to 100 ug/kg/day, and was ...
-
Article
Radiometric dating of sediments using fission tracks in conodonts
Conodonts are microfossils which are commonly found in marine rocks of Cambrian to Triassic age. Although their biological affinities are difficult to assess, conodonts are valuable stratigraphical indices for...
-
Article
Anaesthesia for posterior cervical osteotomy
We have studied 22 consecutive cases of posterior cervical osteotomy done at the Toronto East General Hospital between October 1967 and November 1973.