2,380 Result(s)
within
Science, Humanities and Social Sciences, multidisciplinary
-
Article
Open AccessThe thioredoxin system determines CHK1 inhibitor sensitivity via redox-mediated regulation of ribonucleotide reductase activity
Checkpoint kinase 1 (CHK1) is critical for cell survival under replication stress (RS). CHK1 inhibitors (CHK1i’s) in combination with chemotherapy have shown promising results in preclinical studies but have d...
-
Article
Open AccessRobotic wireless capsule endoscopy: recent advances and upcoming technologies
Wireless capsule endoscopy (WCE) offers a non-invasive evaluation of the digestive system, eliminating the need for sedation and the risks associated with conventional endoscopic procedures. Its significance l...
-
Article
Open AccessFunctional and structural dissection of glycosyltransferases underlying the glycodiversity of wolfberry-derived bioactive ingredients lycibarbarspermidines
Lycibarbarspermidines are unusual phenolamide glycosides characterized by a dicaffeoylspermidine core with multiple glycosyl substitutions, and serve as a major class of bioactive ingredients in the wolfberry....
-
Article
Nano-achiral complex composites for extreme polarization optics
Composites from 2D nanomaterials show uniquely high electrical, thermal and mechanical properties1,2. Pairing their robustness with polarization rotation is needed for hyperspectral optics in extreme conditions3,
-
Article
Open AccessEvaluation and impact factors of international competitiveness of China’s cobalt industry from the perspective of trade networks
In recent years, with the development of the new energy industry, the demand for cobalt as a raw material for power batteries has been increasing. However, China itself has a shortage of cobalt resources. Ther...
-
Article
Open AccessDomain wall magnetic tunnel junction-based artificial synapses and neurons for all-spin neuromorphic hardware
We report a breakthrough in the hardware implementation of energy-efficient all-spin synapse and neuron devices for highly scalable integrated neuromorphic circuits. Our work demonstrates the successful execut...
-
Article
Open AccessVoronoi cell finite element method for heat conduction analysis of composite materials
In this paper, Voronoi cell finite element method (VCFEM) based on assumed flux hybrid formulation has been presented for heat conduction problem of particle reinforced composites material. The heat fluxes sat...
-
Article
Open AccessConstruction of high-quality genomes and gene catalogue for culturable microbes of sugarcane (Saccharum spp.)
Microbes living inside or around sugarcane (Saccharum spp.) are crucial for their resistance to abiotic and biotic stress, growth, and development. Sequences of microbial genomes and genes are helpful to understa...
-
Article
Open AccessTracking the scaling of urban open spaces in China from 1990 to 2020
Urban open spaces (UOS) are crucial for urban life, offering benefits across individual and societal levels. However, the understanding of the systematic dynamic of UOS scaling with city size and its potential...
-
Article
Open AccessSegmentation of void defects in X-ray images of chip solder joints based on PCB-DeepLabV3 algorithm
Defects within chip solder joints are usually inspected visually for defects using X-ray imaging to obtain images. The phenomenon of voids inside solder joints is one of the most likely types of defects in the...
-
Article
Open AccessBalanced opioid-free anesthesia with lidocaine and esketamine versus balanced anesthesia with sufentanil for gynecological endoscopic surgery: a randomized controlled trial
In this randomized controlled trial, 74 patients scheduled for gynecological laparoscopic surgery (American Society of Anesthesiologists grade I/II) were enrolled and randomly divided into two study groups: (i...
-
Article
Open AccessResearch and experimental verification of lightweight loader rims
The safety performance and structural stiffness of a rim, which is the main load-bearing structure of the loader during operation, influence the overall performance, stability, and braking capabilities of the ...
-
Article
Open AccessAssociation between life’s essential 8 and overactive bladder
Limited research has explored the relationship between overactive bladder (OAB) and cardiovascular health (CVH). We aim to examine the correlation between OAB and CVH in American adults, utilizing the Life’s E...
-
Article
Open AccessNylons with Highly-Bright and Ultralong Organic Room-Temperature Phosphorescence
Endowing the widely-used synthetic polymer nylon with high-performance organic room-temperature phosphorescence would produce advanced materials with a great potential for applications in daily life and indust...
-
Article
Open AccessArtificial intelligence enables precision diagnosis of cervical cytology grades and cervical cancer
Cervical cancer is a significant global health issue, its prevalence and prognosis highlighting the importance of early screening for effective prevention. This research aimed to create and validate an artific...
-
Article
Open AccessDihydroartemisinin-driven selective anti-lung cancer proliferation by binding to EGFR and inhibition of NRAS signaling pathway-induced DNA damage
Chemotherapeutic agents can inhibit the proliferation of malignant cells due to their cytotoxicity, which is limited by collateral damage. Dihydroartemisinin (DHA), has a selective anti-cancer effect, whose ta...
-
Article
Open AccessEvaluating nomogram models for predicting survival outcomes in gastric gastrointestinal stromal tumors with SEER database analysis
Gastrointestinal stromal tumors (GISTs) predominantly develop in the stomach. While nomogram offer tremendous therapeutic promise, there is yet no ideal nomogram comparison customized specifically for handling...
-
Article
Open AccessTargeting SOX13 inhibits assembly of respiratory chain supercomplexes to overcome ferroptosis resistance in gastric cancer
Therapeutic resistance represents a bottleneck to treatment in advanced gastric cancer (GC). Ferroptosis is an iron-dependent form of non-apoptotic cell death and is associated with anti-cancer therapeutic eff...
-
Article
Open AccessEcological risk and spatial distribution, sources of heavy metals in typical purple soils, southwest China
The identification and quantification of the ecological risks, sources and distribution of heavy metals in purple soils are essential for regional pollution control and management. In this study, geo-accumulat...
-
Article
Open AccessResearch on a capacitive particle analysis smoke detector
Smoke detectors face the challenges of increasing accuracy, sensitivity, and high reliability in complex use environments to ensure the timeliness, accuracy, and reliability of very early fire detection. The i...
