170 Result(s)
within
Alberto Mantovani
English
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Article
Open AccessSARS-CoV-2 serology in 4000 health care and administrative staff across seven sites in Lombardy, Italy
Lombardy is the Italian region most affected by COVID-19. We tested the presence of plasma anti-SARS-CoV-2 IgG antibodies in 3985 employees across 7 healthcare facilities in areas of Lombardy with different ex...
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Tumor-associated myeloid cells: diversity and therapeutic targeting
Myeloid cells in tumor tissues constitute a dynamic immune population characterized by a non-uniform phenotype and diverse functional activities. Both tumor-associated macrophages (TAMs), which are more abunda...
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Author Correction: A guiding map for inflammation
A Correction to this paper has been published: https://doi.org/10.1038/ni.3790
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COVID-19 vaccines: where we stand and challenges ahead
In the eleven months elapsed since the identification of the SARS-CoV-2 virus and its genome, an exceptional effort by the scientific community has led to the development of over 300 vaccine projects. Over 40 ...
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Complement activation promoted by the lectin pathway mediates C3aR-dependent sarcoma progression and immunosuppression
Complement has emerged as a component of tumor-promoting inflammation. We conducted a systematic assessment of the role of complement activation and effector pathways in sarcomas. C3−/−, MBL1/2−/− and C4−/− mice ...
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Adoptive T-Cell Therapy: Optimizing Chemokine Receptor-Mediated Homing of T-Cells in Cancer Immunotherapy
Immunotherapy based on adoptive T-cell transfer provides a promising form of cancer therapy, but often fails to induce long-lasting responses in the great majority of patients. During the past few decades, sev...
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Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19
Long pentraxin 3 (PTX3) is an essential component of humoral innate immunity, involved in resistance to selected pathogens and in the regulation of inflammation1–3. The present study was designed to assess the pr...
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The other side of the innate immune system: humoral arms favoring cancer
Cancer cells take advantage of NETosis to escape host immune surveillance and mediate metastasis. The pharmacological targeting of NETosis may prove beneficial in maximizing the response to cancer immunotherapy.
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Neutrophil diversity and plasticity in tumour progression and therapy
Neutrophils play a key role in defence against infection and in the activation and regulation of innate and adaptive immunity. In cancer, tumour-associated neutrophils (TANs) have emerged as an important compo...
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Ten things we learned about COVID-19
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Determination of pentraxin 3 levels in cerebrospinal fluid during central nervous system infections
Pentraxin 3 (PTX3) is an acute phase protein; its plasmatic levels significantly rise during severe infections. Data on PTX3 levels in cerebrospinal fluid (CSF) of patients with central nervous system (CNS) in...
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Tumor-Associated Myeloid Cells in Cancer Progression
The tumor microenvironment plays a pivotal role in orchestrating tumor initiation, progression, and spreading, as well as response to therapy. Myeloid immune cells infiltrating tumors are integral component of...
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Open AccessCharacterization of potential biomarkers of reactogenicity of licensed antiviral vaccines: randomized controlled clinical trials conducted by the BIOVACSAFE consortium
Biomarkers predictive of inflammatory events post-vaccination could accelerate vaccine development. Within the BIOVACSAFE framework, we conducted three identically designed, placebo-controlled inpatient/outpat...
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Chronic inflammation in the etiology of disease across the life span
Although intermittent increases in inflammation are critical for survival during physical injury and infection, recent research has revealed that certain social, environmental and lifestyle factors can promote...
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‘Stealth’ corporate innovation: an emerging threat for therapeutic drug development
Therapeutic innovations of potentially great clinical impact should embrace the overarching values of research accountability, data transparency and validation through the scientific peer-review process.
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Author Correction: ‘Stealth’ corporate innovation: an emerging threat for therapeutic drug development
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Open AccessThe great debate at “Immunotherapy Bridge 2018”, Naples, November 29th, 2018
As part of the 2018 Immunotherapy Bridge congress (November 28–29, Naples, Italy), the Great Debate session featured counterpoint views from leading experts on four topical clinical issues in immunotherapy tod...
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The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell–mediated resistance to metastasis
The plasma membrane tetraspan molecule MS4A4A is selectively expressed by macrophage-lineage cells, but its function is unknown. Here we report that MS4A4A was restricted to murine and human mononuclear phagoc...
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Open AccessReport from the BfR expert hearing on practicability of hormonal measurements: recommendations for experimental design of toxicological studies with integrated hormonal end points
This publication summarizes discussions that were held during an international expert hearing organized by the German Federal Institute for Risk Assessment (BfR) in Berlin, Germany, in October 2017. The expert...
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Open AccessThe Ramazzini Institute 13-week pilot study glyphosate-based herbicides administered at human-equivalent dose to Sprague Dawley rats: effects on development and endocrine system
Glyphosate-based herbicides (GBHs) are broad-spectrum herbicides that act on the shikimate pathway in bacteria, fungi, and plants. The possible effects of GBHs on human health are the subject of an intense pub...
