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Open AccessSingle-cell analysis identifies conserved features of immune dysfunction in simulated microgravity and spaceflight
Microgravity is associated with immunological dysfunction, though the mechanisms are poorly understood. Here, using single-cell analysis of human peripheral blood mononuclear cells (PBMCs) exposed to short ter...
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Article
Open AccessTelomeric RNA (TERRA) increases in response to spaceflight and high-altitude climbing
Telomeres are repetitive nucleoprotein complexes at chromosomal termini essential for maintaining genome stability. Telomeric RNA, or TERRA, is a previously presumed long noncoding RNA of heterogeneous lengths...
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Open AccessSingle-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, cell-type, and sex-specific responses to spaceflight
Spaceflight induces an immune response in astronauts. To better characterize this effect, we generated single-cell, multi-ome, cell-free RNA (cfRNA), biochemical, and hematology data for the SpaceX Inspiration...
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Article
Association of biological aging with frailty and post-transplant outcomes among adults with cirrhosis
Frailty is classically associated with advanced age but is also an important predictor of clinical outcomes in comparatively young adults with cirrhosis. We examined the association of biological aging with fr...
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Spatial map** of cellular senescence: emerging challenges and opportunities
Cellular senescence is a well-established driver of aging and age-related diseases. There are many challenges to map** senescent cells in tissues such as the absence of specific markers and their relatively ...
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Article
SARS-CoV-2, COVID-19 and the aging immune system
The coronavirus disease 2019 (COVID-19) pandemic is a global health threat with particular risk for severe disease and death in older adults and in adults with age-related metabolic and cardiovascular disease....
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Author Correction: An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging
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An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging
While many diseases of aging have been linked to the immunological system, immune metrics capable of identifying the most at-risk individuals are lacking. From the blood immunome of 1,001 individuals aged 8–96...
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Chronic inflammation in the etiology of disease across the life span
Although intermittent increases in inflammation are critical for survival during physical injury and infection, recent research has revealed that certain social, environmental and lifestyle factors can promote...
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A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring
Immune responses generally decline with age. However, the dynamics of this process at the individual level have not been characterized, hindering quantification of an individual’s immune age. Here, we use mult...
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Systems immunology: just getting started
Davis and colleagues review systems-biology approaches in immunology as a powerful means of understanding the immune system as a whole.
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Electronic structure of β-NiOOH with hydrogen vacancies and implications for energy conversion applications
Nickel oxide-based materials have attracted significant interest for a variety of energy conversion applications although many of their structures remain unresolved. In this study, Density Functional Theory+U ...
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Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states
Differential expression of inflammasome gene modules and inflammasome-activating metabolites correlates with interleukin-1β expression, hypertension, arterial stiffness and longevity in older individuals.
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Open AccessA phase I clinical study of vaccination of melanoma patients with dendritic cells loaded with allogeneic apoptotic/necrotic melanoma cells. Analysis of toxicity and immune response to the vaccine and of IL-10 -1082 promoter genotype as predictor of disease progression
Sixteen melanoma patients (1 stage IIC, 8 stage III, and 7 stage IV) were treated in a Phase I study with a vaccine (DC/Apo-Nec) composed of autologous dendritic cells (DCs) loaded with a mixture of apoptotic/...
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Open AccessMonocyte-derived dendritic cells loaded with a mixture of apoptotic/necrotic melanoma cells efficiently cross-present gp100 and MART-1 antigens to specific CD8+ T lymphocytes
In the present study, we demonstrate, in rigorous fashion, that human monocyte-derived immature dendritic cells (DCs) can efficiently cross-present tumor-associated antigens when co-cultured with a mixture of ...
