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Article
Genetic predictors of severe intraventricular hemorrhage in extremely low-birthweight infants
To test associations between grades 3 or 4 (severe) intraventricular hemorrhage (IVH) and single nucleotide polymorphisms (SNPs) associated with coagulation, inflammation, angiogenesis, and organ development i...
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Living Reference Work Entry In depth
Logistic Regression
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Living Reference Work Entry In depth
Longitudinal Data Analysis
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Article
Neonatal oxygen saturations and blood pressure at school-age in children born extremely preterm: a cohort study
To explore the relationship between neonatal oxygen saturation and BP at age 6–7 years in a cohort of infants born extremely preterm.
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Article
Is routine evaluation of gastric residuals for premature infants safe or effective?
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Article
Lack of social support as measured by the Family Resource Scale screening tool is associated with early adverse cognitive outcome in extremely low birth weight children
Extremely low birth weight children are at high risk for cognitive impairment.
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Article
Inadequate oral feeding as a barrier to discharge in moderately preterm infants
The objectives describe the frequency that inadequate oral feeding (IOF) is the reason why moderately preterm (MPT) infants remain hospitalized and its association with neonatal morbidities.
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Article
Birth weight discordance in very low birth weight twins: mortality, morbidity, and neurodevelopment
Examine outcomes among birth weight concordant and discordant 401–1500 g twins.
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Article
Prolonged duration of early antibiotic therapy in extremely premature infants
Prolonged early antibiotics in extremely premature infants may have negative effects. We aimed to assess prevalence and outcomes of provision of prolonged early antibiotics to extremely premature infants in th...
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Article
Association between sedation–analgesia and neurodevelopment outcomes in neonatal hypoxic-ischemic encephalopathy
To evaluate the association between sedation–analgesia (SA) during initial 72 h and death/disability at 18 months of age in neonatal hypoxic-ischemic encephalopathy (HIE).
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Article
Open AccessMilrinone in congenital diaphragmatic hernia – a randomized pilot trial: study protocol, review of literature and survey of current practices
Congenital diaphragmatic hernia (CDH) is commonly associated with pulmonary hypoplasia and pulmonary hypertension (PH). PH associated with CDH (CDH-PH) is frequently resistant to conventional pulmonary vasodil...
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Article
Neonatal outcomes of moderately preterm infants compared to extremely preterm infants
Extremely preterm infants (EPT, <29 weeks’ gestation) represent only 0.9% of births in the United States; yet these infants are the focus of most published research. Moderately preterm neonates (MPT, 29–336/7 wee...
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Article
Open AccessAnthropometric indices for non-pregnant women of childbearing age differ widely among four low-middle income populations
Maternal stature and body mass indices (BMI) of non-pregnant women (NPW) of child bearing age are relevant to maternal and offspring health. The objective was to compare anthropometric indices of NPW in four r...
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Article
Safety and pharmacokinetics of multiple dose myo-inositol in preterm infants
Preterm infants with respiratory distress syndrome (RDS) given inositol had reduced bronchopulmonary dysplasia (BPD), death and severe retinopathy of prematurity (ROP). We assessed the safety and pharmacokinet...
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Article
Open AccessAdvantages of Bayesian monitoring methods in deciding whether and when to stop a clinical trial: an example of a neonatal cooling trial
Decisions to stop randomized trials are often based on traditional P value thresholds and are often unconvincing to clinicians. To familiarize clinical investigators with the application and advantages of Bayesia...
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Article
Open AccessStop** guidelines for an effectiveness trial: what should the protocol specify?
Despite long-standing problems in decisions to stop clinical trials, stop** guidelines are often vague or unspecified in the trial protocol. Clear, well-conceived guidelines are especially important to assis...
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Article
Open AccessInhaled PGE1 in neonates with hypoxemic respiratory failure: two pilot feasibility randomized clinical trials
Inhaled nitric oxide (INO), a selective pulmonary vasodilator, has revolutionized the treatment of neonatal hypoxemic respiratory failure (NHRF). However, there is lack of sustained improvement in 30 to 46% of...
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Article
Cytokines associated with necrotizing enterocolitis in extremely-low-birth-weight infants
The goal was to identify cytokines associated with necrotizing enterocolitis (NEC). Based on our earlier reports of decreased tissue expression of transforming growth factor (TGF)-β, we hypothesized that infan...
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Article
Open AccessPreconception maternal nutrition: a multi-site randomized controlled trial
Research directed to optimizing maternal nutrition commencing prior to conception remains very limited, despite suggestive evidence of its importance in addition to ensuring an optimal nutrition environment in...
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Article
Apolipoprotein E genotype and outcome in infants with hypoxic–ischemic encephalopathy
Adults with the apolipoprotein E (APOE) gene alleles e4 and e2 are at high risk of poor neurological outcome after brain injury. The e4 allele has been associated with cerebral palsy (CP), and the e2 allele ha...
