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Open AccessPrescribing practices of inhaled corticosteroids for premature infants in the neonatal intensive care unit
Despite limited safety and efficacy data, inhaled corticosteroids (ICS) are prescribed to premature infants in the neonatal intensive care unit (NICU). We examined contemporary use and risk factors for ICS use...
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Article
Association of maternal pre-pregnancy or first trimester body mass index with neurodevelopmental impairment or death in extremely low gestational age neonates
To compare the rates of death or survival with severe neurodevelopmental impairment (sNDI) at 2 years among extremely preterm infants in relation to pre-pregnancy or first-trimester maternal body mass index (B...
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Article
A phase I trial of caffeine to evaluate safety in infants with hypoxic-ischemic encephalopathy
Caffeine provides neuroprotection following hypoxic-ischemic injury in animals. We characterized the safety of escalating doses of caffeine in infants with hypoxic-ischemic encephalopathy (HIE) receiving thera...
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Article
Morbidity and mortality of twins and triplets compared to singleton infants delivered between 26–34 weeks gestation in the United States
To describe in-hospital morbidities and mortality among twins and triplets delivered at ≥26 to ≤34 weeks gestational age (GA) while controlling for prematurity and growth restriction.
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Article
Trends in COVID-19 diagnoses and outcomes in infants hospitalized in the neonatal intensive care unit
Characterize the prevalence of coronavirus disease 2019 (COVID-19) diagnosis among mothers with infants hospitalized in 294 neonatal intensive care units (NICUs), and demographics and outcomes of infants with ...
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Article
Risk factors and epidemiology of spontaneous intestinal perforation among infants born at 22–24 weeks’ gestational age
To describe the epidemiology, risk factors, and timing of spontaneous intestinal perforation (SIP) among infants born at 22–24 weeks’ gestational age (GA).
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Article
Underimmunization of very low birth weight infants at discharge from the neonatal intensive care unit
To quantify immunization status among premature infants discharged from neonatal intensive care units (NICUs), and identify risk factors for underimmunization.
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Trends in morbidities of late preterm infants in the neonatal intensive care unit
To characterize demographics and trends in length of stay (LOS), morbidities, and mortality in late preterm infants.
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Article
Use of vasopressors for septic shock in the neonatal intensive care unit
To describe outcomes for infants in the neonatal intensive care unit with septic shock based on the vasopressor administered.
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Article
Early antibiotic exposure in very-low birth weight infants and infection risk at 3–7 days after birth
To determine rates of late-onset infection (LOI) during postnatal days 3–7 among preterm infants, based on antibiotic exposure during days 0–2.
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Open AccessEndotoxin content in neonatal formulas, fortification, and lactoferrin products: association with outcomes and guidance on acceptable limits
While endotoxin (lipopolysaccharide) can be harmful and contribute to morbidity and mortality with Gram-negative sepsis or necrotizing enterocolitis in preterm infants, non-toxic amounts are produced as part o...
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Article
Congenital anomalies of the kidney and urinary tract (CAKUT) in critically ill infants: a multicenter cohort study
The aim of the study was to determine the prevalence of congenital anomalies of the kidney and urinary tract (CAKUT) in the neonatal intensive care unit (NICU) and to evaluate risk factors associated with wors...
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Article
Evaluation and validation of a prediction model for extubation success in very preterm infants
To perform an external validation of a publicly available model predicting extubation success in very preterm infants.
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Article
Open AccessEating, Slee**, Consoling for Neonatal Opioid Withdrawal (ESC-NOW): a Function-Based Assessment and Management Approach study protocol for a multi-center, stepped-wedge randomized controlled trial
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Article
Ampicillin dosing in premature infants for early-onset sepsis: exposure-driven efficacy, safety, and stewardship
Define optimal ampicillin dosing for empiric early-onset sepsis (EOS) therapy in preterm neonates.
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Article
Association between postmenstrual age and furosemide dosing practices in very preterm infants
Furosemide renal clearance is slow after very preterm (VP) birth and increases with postnatal maturation. We compared furosemide dose frequency and total daily dose between postmenstrual age (PMA) groups in VP...
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Article
Population Pharmacokinetics of Moxifloxacin in Children
Moxifloxacin is a fluoroquinolone that is commonly used in adults, but not children. Certain clinical situations compel pediatric clinicians to use moxifloxacin, despite its potential for toxicity and limited ...
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Article
Physiologically Based Pharmacokinetic Modeling of Meropenem in Preterm and Term Infants
Meropenem is a broad-spectrum carbapenem antibiotic approved by the US Food and Drug Administration for use in pediatric patients, including treating complicated intra-abdominal infections in infants < 3 month...
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Article
Comparative efficacy and safety of late surfactant preparations: a retrospective study
Characterize the use, efficacy, and safety of poractant alfa and calfactant surfactants compared to beractant in preterm infants receiving late surfactant.
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Article
Covariation of changing patent ductus arteriosus management and preterm infant outcomes in Pediatrix neonatal intensive care units
To test the hypothesis that NICU-specific preterm infant outcomes co-vary with changes in local patent ductus arteriosus (PDA) management.