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Article
P3H4 Regulates Apoptosis and Autophagy of Breast Cancer Cells via BCL-2/BAX/Caspase-3 and AMPK/mTOR/ULK1 Signaling Pathways
The role of prolyl 3-hydroxylase family member 4 (P3H4, or SC65) in breast cancer and the molecular mechanisms in which this protein was involved were investigated. For this purpose, microchips with cancerous ...
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Article
Effects of Diffuse Light Film Rain Shelter on the Growth and Fruit Quality of Fresh Grape
Scattered light can make the distribution of light in plant canopies more uniform. In this study, Vitis vinifera L. ‘Wuhe Cuibao’ fresh grapes was used as the test material, and open field cultivation was used as...
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Article
\(hp\) -Optimal Interior Penalty Discontinuous Galerkin Methods for the Biharmonic Problem
We prove \(hp\) hp -optimal error es...
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Article
Dietary Methionine and Total Sulfur Amino Acid Restriction in Healthy Adults
Dietary restriction of methionine (Met) and cysteine (Cys) delays the aging process and aging-related diseases, improves glucose and fat metabolism and reduces oxidative stress in numerous laboratory animal mo...
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Article
Determination of Activation Energy and Prediction of Long-Term Strength of Creep Rupture for Alloy Inconel 740/740H: A Method Based on a New Tensile Creep Rupture Model
The activation energy of creep rupture is determined based on a new tensile creep rupture model and then applied to rationalize the creep rupture data measured over a wide range of stresses and temperatures, w...
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Article
Caloric restriction and Roux-en-Y Gastric Bypass promote white adipose tissue browning in mice
Caloric restriction (CR) and Roux-en-Y Gastric Bypass (RYGB) are considered effective means of body weight control, but the mechanism by which CR and RYGB protect against high-fat diet (HFD)-induced obesity re...
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Article
Fizeau drag in graphene plasmonics
Dragging of light by moving media was predicted by Fresnel1 and verified by Fizeau’s celebrated experiments2 with flowing water. This momentous discovery is among the experimental cornerstones of Einstein’s speci...
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Article
Comparative Study of Wound-Healing Activity of Dihydroquercetin Pseudopolymorphic Modifications
Wound-healing activity of the crystalline form of dihydroquercetin and its microtubular pseudopolymorphic modification obtained by crystal engineering was compared using the rat model of IIIA degree burn. The ...
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Article
Serum Stem Cell Factor Level Predicts Decline in Kidney Function in Healthy Aging Adults
Stem cell factor (SCF), the ligand of the c-kit receptor, actively participates in the organ reconstruction and fibrosis associated with various diseases, including kidney disease. However, it remains unclear ...
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Article
Open AccessImplication of lymph node staging in migration and different treatment strategies for stage T2N0M0 and T1N1M0 resected gastric cancer: a SEER population analysis
The purpose of this study was to explore the differences between stage T2N0M0 and stage T1N1M0 gastric cancer (GC) and to identify the necessity of adjuvant treatment (AT) for these stages.
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Article
Rationalization of Short-Term Creep Test Data and Prediction of Long-Term Creep Strengths of a Fe-20Cr-25Ni (Wt Pct) Austenitic Stainless Steel (Alloy 709)
A new creep model is applied to rationalize the stress and temperature dependences of minimum creep rate for a Fe-20Cr-25Ni (wt pct) austenitic stainless steel (Alloy 709). The creep activation energy determin...
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Article
Simulation of the Spindle Coupled Multi-Axial Loading Fatigue Test of a Minivan Rear Axle
This study aims to establish a practical method for simulating the spindle coupled multi-axial loading fatigue test of a rear axle. A dynamic finite element model of the minivan rear axle was constructed and v...
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Article
Open AccessCombination curcumin and (−)-epigallocatechin-3-gallate inhibits colorectal carcinoma microenvironment-induced angiogenesis by JAK/STAT3/IL-8 pathway
Tumor microenvironment has a crucial role in cancer development and progression, whereas the mechanism of how it regulates angiogenesis is unclear. In this study, we simulated the colorectal carcinoma microenv...
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Article
Soybean NAC gene family: sequence analysis and expression under low nitrogen supply
NAM, ATAF1/2, and CUC2 (NAC) proteins are plant-specific transcription factors playing essential roles in plant development and various abiotic stress responses. In the present study, we identified 173 full-le...
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Article
Open AccessPhosphorylation of NFAT3 by CDK3 induces cell transformation and promotes tumor growth in skin cancer
The nuclear factor of activated T cells (NFAT) family proteins are transcription factors that regulate the expression of pro-inflammatory cytokines and other genes during the immune response. Although the NFAT...
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Article
Deficits in striatal dopamine release in cannabis dependence
Most drugs of abuse lead to a general blunting of dopamine release in the chronic phase of dependence, which contributes to poor outcome. To test whether cannabis dependence is associated with a similar dopami...
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Article
Open AccessFocused screening of mitochondrial metabolism reveals a crucial role for a tumor suppressor Hbp1 in ovarian reserve
Granulosa cells (GCs) are tightly associated with fertility and the fate of ovarian follicles. Mitochondria are the central executers of apoptosis. However, the genetic basis underlying mitochondrial modulatio...
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Article
Dual Improvement of Red Emission and Ferroelectric Properties in Plumbum-Free Ba4La0.666−x Eu x Nb10O30 Ceramics
Luminescent ferroelectric materials (LFM) have attracted considerable attention in recent years for the design and development of new multifunctional devices. In this work, different from conventional perovski...
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Article
Fyn is a redox sensor involved in solar ultraviolet light-induced signal transduction in skin carcinogenesis
Solar ultraviolet (UV) light is a major etiological factor in skin carcinogenesis, with solar UV-stimulated signal transduction inducing pathological changes and skin damage. The primary sensor of solar UV-ind...
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Article
PDK1 promotes tumor growth and metastasis in a spontaneous breast cancer model
Because malignant cells have altered, usually accelerated, energy consumption, targeting metabolic signaling represents a prevailing strategy for tumor therapy. Phosphoinositide-dependent kinase 1 (PDK1) is a ...
