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Article
Dietary Methionine and Total Sulfur Amino Acid Restriction in Healthy Adults
Dietary restriction of methionine (Met) and cysteine (Cys) delays the aging process and aging-related diseases, improves glucose and fat metabolism and reduces oxidative stress in numerous laboratory animal mo...
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Article
Association of dietary sulfur amino acid intake with mortality from diabetes and other causes
Sulfur amino acid (SAA) consumption in Western countries is far greater than recommended levels. In preclinical studies, reduced SAA intake enhanced longevity and reduced risk for numerous chronic diseases. Th...
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Article
Open AccessProspective study of dietary mushroom intake and risk of mortality: results from continuous National Health and Nutrition Examination Survey (NHANES) 2003-2014 and a meta-analysis
Whether mushroom consumption, which is a rich source of potent antioxidants ergothioneine and glutathione, vitamins, and minerals (e.g., selenium & copper), is associated with a lower mortality risk is not wel...
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Article
Open AccessAssociation of mushroom consumption with all-cause and cause-specific mortality among American adults: prospective cohort study findings from NHANES III
Whether mushroom consumption, which is rich in several bioactive compounds, including the crucial antioxidants ergothioneine and glutathione, is inversely associated with low all-cause and cause-specific morta...
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Article
Methionine restriction delays aging-related urogenital diseases in male Fischer 344 rats
Dietary methionine restriction (MR) has been found to enhance longevity across many species. We hypothesized that MR might enhance longevity in part by delaying or inhibiting age-related disease processes. To ...
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Article
Dietary methionine influences therapy in mouse cancer models and alters human metabolism
Nutrition exerts considerable effects on health, and dietary interventions are commonly used to treat diseases of metabolic aetiology. Although cancer has a substantial metabolic component1, the principles that d...
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Article
Open AccessCorrection to Reduced nicotine content cigarettes in smokers of low socioeconomic status: study protocol for a randomized control trial
The title of the original publication [1] had an error; furthermore there were errors in Fig. 2. The corrected version of the title and of Fig. 2 can be found below in this Erratum.
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Article
Open AccessReduced nicotine content cigarettes in smokers of low socioeconomic status: study protocol for a randomized control trial
The Family Smoking Prevention and Tobacco Control Act gave the Food and Drug Administration jurisdiction over the regulation of all tobacco products, including their nicotine content. Under this act, a major s...
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Article
Response to Letter to the Editor from Dr. Guilford
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Article
Randomized controlled trial of oral glutathione supplementation on body stores of glutathione
Glutathione (GSH), the most abundant endogenous antioxidant, is a critical regulator of oxidative stress and immune function. While oral GSH has been shown to be bioavailable in laboratory animal models, its ...
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Article
The nicotine dependence phenotype, time to first cigarette, and larynx cancer risk
Cigarette smoking is the major cause of laryngeal cancer. The time to first cigarette after waking in the morning is a behavior associated with several dimensions of nicotine dependence including the dose of s...
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Article
The Effects of Tamoxifen and Fish Oil on Mammary Carcinogenesis in Polyoma Middle T Transgenic Mice
In these experiments, we tested the hypothesis that inhibition of the estrogen receptor (ER) with Tamoxifen and activation of PPARγ with fish oil (FO) rich in omega-3 (n-3; known PPAR agonists) inhibit the dev...
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Article
Formation of 8-oxodeoxyguanosine in brain DNA of rats exposed to acrylonitrile
Acrylonitrile (ACN) produces tumors in rats, particularly gliomas of the brain, but tests for genotoxicity have yielded mixed results and no ACN-DNA adducts have been identified in the brain. To examine the p...
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Chapter
The Effect of Animal Age on Tumor Induction
One of the major factors that affects the induction of cancer by chemical compounds, and which has not yet been thoroughly investigated, is the age of the host. As a number of significant metabolic changes occ...
