307 Result(s)
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Article
Cloning and characterization of a mouse liver-specific gene mfrep-1, upregulated in liver regeneration
Human fibrinogen-related protein-1/liver fibrinogen-related protein-1 (HFREP-1/LFIRE-1), a liver-specific protein, is a member of fibrinogen superfamily that exerts various biological activities. However, the ...
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Article
Embryonic stem cells generated by nuclear transfer of human somatic nuclei into rabbit oocytes
To solve the problem of immune incompatibility, nuclear transplantation has been envisaged as a means to produce cells or tissues for human autologous transplantation. Here we have derived embryonic stem cells...
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Arabidopsis RAV1 is down-regulated by brassinosteroid and may act as a negative regulator during plant development
RAV1 is a novel DNA-binding protein with two distinct DNA-binding domains unique in higher plants, but its role in plant growth and development remains unknown. Using cDNA array, we found that transcription of RA...
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Open AccessCurrent limitations of SNP data from the public domain for studies of complex disorders: a test for ten candidate genes for obesity and osteoporosis
Public SNP databases are frequently used to choose SNPs for candidate genes in the association and linkage studies of complex disorders. However, their utility for such studies of diseases with ethnic-dependen...
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Open AccessPatterns of linkage disequilibrium and haplotype distribution in disease candidate genes
The adequacy of association studies for complex diseases depends critically on the existence of linkage disequilibrium (LD) between functional alleles and surrounding SNP markers.
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Cloning and functional characterization of two cDNAs encoding NADPH-dependent 3-ketoacyl-CoA reductased from develo** cotton fibers
Genes encoding enzymes involved in biosynthesis of very long chain fatty acids were significantly up-regulated during early cotton fiber development. Two cDNAs, GhKCR1 and GhKCR2 encoding putative cotton 3-ketoac...
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A New Cadinane Sesquiterpene with Significant Anti-HIV-1 Activity from the Cultures of the Basidiomycete Tyromyces chioneus
A new cadinane sesquiterpene (4β,14-dihydroxy-6α,7βH-1(10)-cadinene, 1) was isolated from the cultures of the basidiomycete, Tyromyces chioneus. Its structure was established on the basis of spectral measurements...
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Article
Selection of oocytes for in vitro maturation by brilliant cresyl blue staining: a study using the mouse model
Selecting oocytes that are most likely to develop is crucial for in vitro fertilization and animal cloning. Brilliant cresyl blue (BCB) staining has been used for oocyte selection in large animals, but its wider ...
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Open AccessGenomic analysis of the chromosome 15q11-q13 Prader-Willi syndrome region and characterization of transcripts for GOLGA8E and WHCD1L1 from the proximal breakpoint region
Prader-Willi syndrome (PWS) is a neurobehavioral disorder characterized by neonatal hypotonia, childhood obesity, dysmorphic features, hypogonadism, mental retardation, and behavioral problems. Although PWS is...
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Open AccessComparative study of mesenchymal stem cells from C57BL/10 and mdx mice
Human mesenchymal stem cells (MSCs) have been studied and applied extensively because of their ability to self-renew and differentiate into various cell types. Since most human diseases models are murine, mous...
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Open AccessEpigenetic modification of histone 3 at lysine 9 in sheep zygotes and its relationship with DNA methylation
Previous studies indicated that, unlike mouse zygotes, sheep zygotes lacked the paternal DNA demethylation event. Another epigenetic mark, histone modification, especially at lysine 9 of histone 3 (H3K9), has ...
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Article
Construction of a chloroplast protein interaction network and functional mining of photosynthetic proteins in Arabidopsis thaliana
Chloroplast is a typical plant cell organelle where photosynthesis takes place. In this study, a total of 1 808 chloroplast core proteins in Arabidopsis thaliana were reliably identified by combining the results ...
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Bridging protein local structures and protein functions
One of the major goals of molecular and evolutionary biology is to understand the functions of proteins by extracting functional information from protein sequences, structures and interactions. In this review,...
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Open AccessY chromosome evidence of earliest modern human settlement in East Asia and multiple origins of Tibetan and Japanese populations
The phylogeography of the Y chromosome in Asia previously suggested that modern humans of African origin initially settled in mainland southern East Asia, and about 25,000–30,000 years ago, migrated northward,...
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Open AccessA homogenous nature of native Chinese duck matrilineal pool
China, with around 30 unique breeds, has a diverse duck genetic pool. Currently, there is no systematic report which investigates the genetic diversity, phylogenetic relationship, and matrilineal genetic struc...
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Open AccessIdentifying Positioned Nucleosomes with Epigenetic Marks in Human from ChIP-Seq
In vivo positioning and covalent modifications of nucleosomes play an important role in epigenetic regulation, but genome-wide studies of positioned nucleosomes and their modifications in human still remain limit...
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Velleratretraol, an unusual highly functionalized lactarane sesquiterpene from Lactarius vellereus
An unusual highly functionalized lactarane sesquiterpene, named velleratretraol (1), was isolated from the ethanol extract of the fruiting body of the mushroom Lactarius vellereus. Its structure was determined th...
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Open AccessIdentification and association of the single nucleotide polymorphisms in calpain3 (CAPN3) gene with carcass traits in chickens
The aim of this study is to screen single nucleotide polymorphisms (SNP) of chicken Calpain3 (CAPN3) gene and to analyze the potential association between CAPN3 gene polymorphisms and carcass traits in chickens. ...
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Open AccessCervical cancer isolate PT3, super-permissive for adeno-associated virus replication, over-expresses DNA polymerase δ, PCNA, RFC and RPA
Adeno-associated virus (AAV) type 2 is an important virus due to its use as a safe and effective human gene therapy vector and its negative association with certain malignancies. AAV, a dependo-parvovirus, aut...
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Article
An R2R3-type transcription factor gene AtMYB59 regulates root growth and cell cycle progression in Arabidopsis
MYB proteins play important roles in eukaryotic organisms. In plants, the R1R2R3-type MYB proteins function in cell cycle control. However, whether the R2R3-type MYB protein is also involved in the cell divisi...
