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Article
Open AccessNovel anti-inflammatory diketopiperazine alkaloids from the marine-derived fungus Penicillium brasilianum
Diketopiperazine alkaloids have proven the most abundant heterocyclic alkaloids up to now, which usually process diverse scaffolds and rich biological activities. In our search for bioactive diketopiperazine a...
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Article
Design, Synthesis, and Antifungal Activity of Alkyl Gallates Against Plant Pathogenic Fungi In Vitro and In Vivo
A series of alkyl gallates was synthesized by reacting gallic acid with the corresponding alcohols. Their structures were determined on the basis of spectroscopic data, including NMR and MS. The antifungal act...
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Article
Isolation and Cytotoxicity of Isocoumarins from the Entomogenous Fungus Setosphaeria sp.
A new isocoumarin compound named setosphacohol A (1), together with six known ones, alternariol (2), isoaltenuene (3), phomasatin (4), alternariol 5-O-methyl ether (5), 1-deoxyrubralactone (6), and rubralactone (
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Article
A New Polyketide-Derived Metabolite with PTP1B Inhibitory Activity from the Endophytic Fungus Pestalotiopsis neglecta
A new polyketide-derived metabolite, named neglectine A, was isolated from cultures of the endophytic fungus Pestalotiopsis neglecta. Its structure was elucidated by analysis of 1D and 2D spectroscopic data as we...
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Article
Effect of metformin on global gene expression in liver of KKAy mice
Metformin is a first-line drug for treating type 2 diabetes mellitus, yet its mechanism remains only partially understood and controversial. In this study we assessed a global gene expression profiling in live...
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Article
Phthalide derivatives with antifungal activities against the plant pathogens isolated from the liquid culture of Pestalotiopsis photiniae
Three new phthalide derivatives (1-3) named 5-(3′-methyl-2′-butenyl)-2-hydroxy-3-methoxy-4-methylbenzoic acid (1), 5-(3′-carboxyl-3′-methyl-2E-allyloxy)-3-methoxy-4-methylphthalide (2) and 5-(3′,3′-dimethylallylo...
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Article
Velleratretraol, an unusual highly functionalized lactarane sesquiterpene from Lactarius vellereus
An unusual highly functionalized lactarane sesquiterpene, named velleratretraol (1), was isolated from the ethanol extract of the fruiting body of the mushroom Lactarius vellereus. Its structure was determined th...
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Article
Highly Oxidized Humulane Sesquiterpenes from the Basidiomycete Lactarius mitissimus
Two new highly oxidized humulane sesquiterpenes, mitissimols D (1) and E (2) were isolated from the fruiting bodies of Lactarius mitissimus. Their structures were elucidated using extensive spectroscopic techniqu...
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Article
A New Cytotoxic Lanostane Triterpenoid from the Basidiomycete Hebeloma versipelle
A new cytotoxic lanostane triterpenoid, 24(E)-3β-hydroxylanosta-8,24-dien-26-al-21-oic acid (1), was isolated from the fruiting bodies of the mushroom Hebeloma versipelle. The structure was elucidated on the basi...
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Article
Rufuslactone, a New Antifungal Sesquiterpene from the Fruiting Bodies of the Basidiomycete Lactarius rufus
A new lactarane sesquiterpene, rufuslactone (1), was isolated from the fruiting bodies of the basidiomycete Lactarius rufus. Rufuslactone (1) is an isomer of a previously described lactarane 3,8-oxa-13-hydroxylac...
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Article
Aurovertin E, a New Polyene Pyrone from the Basidiomycete Albatrellus confluens
A new polyene pyrone, aurovertin E (2), was isolated along with aurovertin B (1) from the culture mycelia of the basidiomycete Albatrellus confluens. Their structures were elucidated on the basis of spectroscopic...
