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Article
Binary generalized orthogonal matching pursuit
In signal processing, it is usually to meet the recovery of K-sparse binary signal. In order to reconstruct the K-sparse binary signal, the binary generalized orthogonal matching pursuit (BgOMP) algorithm is pro...
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Article
Open AccessProfiles and integration of the gut microbiome and fecal metabolites in severe intrahepatic cholestasis of pregnancy
The pathogenesis of intrahepatic cholestasis of pregnancy (ICP) remains unknown. The gut microbiome and its metabolites play important roles in bile acid metabolism, and previous studies have indicated the ass...
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Article
Open AccessComprehensive assessment of the utilization of manure in China’s croplands based on national farmer survey data
China’s rapid increase in mass excreta and its environmental discharge have attracted substantial attention. However, cropland as a main destination of excreta utilization has not been extensively evaluated. H...
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Article
Open AccessAcute liver steatosis translationally controls the epigenetic regulator MIER1 to promote liver regeneration in a study with male mice
The early phase lipid accumulation is essential for liver regeneration. However, whether this acute lipid accumulation can serve as signals to direct liver regeneration rather than simply providing building bl...
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Article
High-protein diet prevents fat mass increase after dieting by counteracting Lactobacillus-enhanced lipid absorption
Dietary restriction is widely used to reduce fat mass and lose weight in individuals with or without obesity; however, weight regain after dieting is still a big challenge, and the underlying mechanisms remain...
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Article
Integrating crop redistribution and improved management towards meeting China’s food demand with lower environmental costs
China feeds 19.1% of the world’s population with 8.6% of the arable land. Here we propose an integrated approach combining crop redistribution and improved management to meet China’s food demand in 2030. We si...
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Article
Open AccessHepatic thyroid hormone signalling modulates glucose homeostasis through the regulation of GLP-1 production via bile acid-mediated FXR antagonism
Thyroid hormones (TH) regulate systemic glucose metabolism through incompletely understood mechanisms. Here, we show that improved glucose metabolism in hypothyroid mice after T3 treatment is accompanied with ...
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Article
Open AccessEstablishment of pediatric developmental dysplasia of the hip biobank: Shanghai children’s hospital experience
Developmental dysplasia of the hip (DDH) is a debilitating condition that affects 1–7% of newborns. Children with DDH, not treated early and effectively, will easily lead to disability. A better understanding ...
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Article
Open AccessTriiodothyronine (T3) promotes brown fat hyperplasia via thyroid hormone receptor α mediated adipocyte progenitor cell proliferation
The thyroid hormone (TH)-controlled recruitment process of brown adipose tissue (BAT) is not fully understood. Here, we show that long-term treatment of T3, the active form of TH, increases the recruitment of ...
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Article
Open AccessSingle cell transcriptomic analysis of human amnion identifies cell-specific signatures associated with membrane rupture and parturition
The human amnion is an intrauterine tissue which is involved in the initiation of parturition. In-depth understanding of gene expression signatures of individual cell types in the amnion with respect to membra...
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Article
Open AccessMultiplexed nanomaterial-assisted laser desorption/ionization for pan-cancer diagnosis and classification
As cancer is increasingly considered a metabolic disorder, it is postulated that serum metabolite profiling can be a viable approach for detecting the presence of cancer. By multiplexing mass spectrometry fing...
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Chapter and Conference Paper
Risk and Regulation of Shadow Banking in China: Analysis from WMP and P2P
In China, shadow banking used to effectively help commercial banks resolve bad debts, but the underlying risks accordingly evolved into systematic risks, and it aroused the government’s concern and action. Thi...
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Article
Optimization of China’s maize and soy production can ensure feed sufficiency at lower nitrogen and carbon footprints
China purchases around 66% of the soy that is traded internationally. This strains the global food supply and contributes to greenhouse gas emissions. Here we show that optimizing the maize and soy production ...
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Article
Open AccessActivation of GCN2/ATF4 signals in amygdalar PKC-δ neurons promotes WAT browning under leucine deprivation
The browning of white adipose tissue (WAT) has got much attention for its potential beneficial effects on metabolic disorders, however, the nutritional factors and neuronal signals involved remain largely unkn...
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Article
MRG15 orchestrates rhythmic epigenomic remodelling and controls hepatic lipid metabolism
The rhythmic regulation of transcriptional processes is intimately linked to lipid homeostasis, to anticipate daily changes in energy access. The Rev-erbα–HDAC3 complex was previously discovered to execute the...
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Article
Open AccessUbiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis
The ubiquitination status of RIPK1 is considered to be critical for cell fate determination. However, the in vivo role for RIPK1 ubiquitination remains undefined. Here we show that mice expressing RIPK1K376R whic...
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Article
Open AccessPre-kidney transplant lower extremity impairment and transplant length of stay: a time-to-discharge analysis of a prospective cohort study
Few objective tests can be performed at admission for kidney transplantation [KT] to discern risk of increased length of stay [LOS], which is important for patient counseling and is associated with increased c...
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Article
Open AccessClosing water productivity gaps to achieve food and water security for a global maize supply
To achieve food and water security, it is as important to close the water productivity (WP) gap (which was defined as the difference between the maximum attainable WP and the currently achieved WP at the field...
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Article
Pursuing sustainable productivity with millions of smallholder farmers
Millions of Chinese smallholder farmers were persuaded to adopt enhanced management practices, which led to a greater yield, reduced nitrogen fertilizer use and improved environmental performance throughout Ch...
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Article
Open AccessEngaging clinicians and patients to assess and improve frailty measurement in adults with end stage renal disease
The Fried frailty phenotype, a measure of physiologic reserve defined by 5 components (exhaustion, unintentional weight loss, low physical activity, slow walking speed, and poor grip strength), is associated w...
