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Article
Open AccessFGFR inhibition blocks NF-ĸB-dependent glucose metabolism and confers metabolic vulnerabilities in cholangiocarcinoma
Genomic alterations that activate Fibroblast Growth Factor Receptor 2 (FGFR2) are common in intrahepatic cholangiocarcinoma (ICC) and confer sensitivity to FGFR inhibition. However, the depth and duration of r...
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Article
SULT1A1-dependent sulfonation of alkylators is a lineage-dependent vulnerability of liver cancers
Adult liver malignancies, including intrahepatic cholangiocarcinoma and hepatocellular carcinoma, are the second leading cause of cancer-related deaths worldwide. Most individuals are treated with either combi...
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Article
Open AccessAuthor Correction: Integrated multi-omics analysis of RB-loss identifies widespread cellular programming and synthetic weaknesses
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Article
Open AccessIntegrated multi-omics analysis of RB-loss identifies widespread cellular programming and synthetic weaknesses
Inactivation of RB is one of the hallmarks of cancer, however gaps remain in our understanding of how RB-loss changes human cells. Here we show that pRB-depletion results in cellular reprogramming, we quantita...
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Article
iDRiP for the systematic discovery of proteins bound directly to noncoding RNA
More than 90% of the human genome is transcribed into noncoding RNAs, but their functional characterization has lagged behind. A major bottleneck in the understanding of their functions and mechanisms has been...
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Article
Decap** enzyme 1A breaks X-chromosome symmetry by controlling Tsix elongation and RNA turnover
How allelic asymmetry is generated remains a major unsolved problem in epigenetics. Here we model the problem using X-chromosome inactivation by develo** “BioRBP”, an enzymatic RNA-proteomic method that enab...
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Article
Open AccessA post-transcriptional program of chemoresistance by AU-rich elements and TTP in quiescent leukemic cells
Quiescence (G0) is a transient, cell cycle-arrested state. By entering G0, cancer cells survive unfavorable conditions such as chemotherapy and cause relapse. While G0 cells have been studied at the transcript...
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Article
Author Correction: LKB1 loss links serine metabolism to DNA methylation and tumorigenesis
An Amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessSETD1A protects from senescence through regulation of the mitotic gene expression program
SETD1A, a Set1/COMPASS family member maintaining histone-H3-lysine-4 (H3K4) methylation on transcriptionally active promoters, is overexpressed in breast cancer. Here, we show that SETD1A supports mitotic process...
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Article
Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism
G protein αs (GNAS) mediates receptor-stimulated cAMP signalling, which integrates diverse environmental cues with intracellular responses. GNAS is mutationally activated in multiple tumour types, although its on...
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Article
Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation
A selective small-molecule degrader of CDK9 was generated by conjugating an imide to SNS-032, a promiscuous ATP-site-directed CDK binder. The pharmacological consequences of CDK9 degradation versus inhibition ...
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Article
Detection of dysregulated protein-association networks by high-throughput proteomics predicts cancer vulnerabilities
Multiplexed mass spectrometry analysis of breast cancer cell lines uncovers co-regulation of protein abundance that predicts the vulnerabilities of different cancers to drugs.
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Article
Open AccessNegative regulation of EGFR signalling by the human folliculin tumour suppressor protein
Germline mutations in the Folliculin (FLCN) tumour suppressor gene result in fibrofolliculomas, lung cysts and renal cancers, but the precise mechanisms of tumour suppression by FLCN remain elusive. Here we ident...
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Article
Open AccessExpression of β-globin by cancer cells promotes cell survival during blood-borne dissemination
Metastasis-competent circulating tumour cells (CTCs) experience oxidative stress in the bloodstream, but their survival mechanisms are not well defined. Here, comparing single-cell RNA-Seq profiles of CTCs fro...
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Article
Open AccessTribbles ortholog NIPI-3 and bZIP transcription factor CEBP-1 regulate a Caenorhabditis elegans intestinal immune surveillance pathway
Many pathogens secrete toxins that target key host processes resulting in the activation of immune pathways. The secreted Pseudomonas aeruginosa toxin Exotoxin A (ToxA) disrupts intestinal protein synthesis, whic...
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Article
LKB1 loss links serine metabolism to DNA methylation and tumorigenesis
Intermediary metabolism generates substrates for chromatin modification, enabling the potential coupling of metabolic and epigenetic states. Here we identify a network linking metabolic and epigenetic alterati...
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Article
HER2 expression identifies dynamic functional states within circulating breast cancer cells
Patient-derived circulating tumour cells are used to characterize the dynamics and underlying plasticity of HER2 expression in non-HER2-amplified breast tumours.
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Multiplexed Quantitative Proteomics for High-Throughput Comprehensive Proteome Comparisons of Human Cell Lines
The proteome is the functional entity of the cell, and perturbations of a cellular system almost always cause changes in the proteome. These changes are a molecular fingerprint, allowing characterization and a...
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Article
Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism
The MiT/TFE family of transcription factors is found to coordinate constitutive activation of autophagy and lysosome biogenesis to drive the metabolic programming and malignant growth of pancreatic cancer.
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Article
Open AccessMetabolic analysis of the loss of Rb1 in vivo
