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  1. No Access

    Article

    Velcrin-induced selective cleavage of tRNALeu(TAA) by SLFN12 causes cancer cell death

    Velcrin compounds kill cancer cells expressing high levels of phosphodiesterase 3A (PDE3A) and Schlafen family member 12 (SLFN12) by inducing complex formation between these two proteins, but the mechanism of ...

    Sooncheol Lee, Stephanie Hoyt, **aoyun Wu, Colin Garvie… in Nature Chemical Biology (2023)

  2. Article

    Open Access

    Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase

    DNMDP and related compounds, or velcrins, induce complex formation between the phosphodiesterase PDE3A and the SLFN12 protein, leading to a cytotoxic response in cancer cells that express elevated levels of bo...

    Colin W. Garvie, **aoyun Wu, Malvina Papanastasiou, Sooncheol Lee… in Nature Communications (2021)

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  3. Article

    Open Access

    A post-transcriptional program of chemoresistance by AU-rich elements and TTP in quiescent leukemic cells

    Quiescence (G0) is a transient, cell cycle-arrested state. By entering G0, cancer cells survive unfavorable conditions such as chemotherapy and cause relapse. While G0 cells have been studied at the transcript...

    Sooncheol Lee, Douglas Micalizzi, Samuel S. Truesdell, Syed I. A. Bukhari… in Genome Biology (2020)

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  4. No Access

    Chapter

    Post-transcriptional Stimulation of Gene Expression by MicroRNAs

    MicroRNAs are small noncoding RNA regulatory molecules that control gene expression by guiding associated effector complexes to other RNAs via sequence-specific recognition of target sites. Misregulation of mi...

    Sooncheol Lee, Shobha Vasudevan in Ten Years of Progress in GW/P Body Research (2013)