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Open AccessA telomere-targeting drug depletes cancer initiating cells and promotes anti-tumor immunity in small cell lung cancer
There are few effective treatments for small cell lung cancer (SCLC) underscoring the need for innovative therapeutic approaches. This study focuses on exploiting telomerase, a critical SCLC dependency as a th...
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Open AccessSETD1A protects from senescence through regulation of the mitotic gene expression program
SETD1A, a Set1/COMPASS family member maintaining histone-H3-lysine-4 (H3K4) methylation on transcriptionally active promoters, is overexpressed in breast cancer. Here, we show that SETD1A supports mitotic process...
