-
Article
Open AccessSingle-cell transcriptomics unveil profiles and interplay of immune subsets in rare autoimmune childhood Sjögren’s disease
Childhood Sjögren’s disease represents critically unmet medical needs due to a complete lack of immunological and molecular characterizations. This study presents key immune cell subsets and their interactions...
-
Article
Attitude Tracking Control of All-Terrain Vehicle with Tandem Active–Passive Suspension
When vehicles with traditional passive suspension systems are driving on complex pavement, the large vibration of the body will result in relatively negative effects on ride comfort, vehicle handling, and stab...
-
Chapter and Conference Paper
Attitude Control of Active Suspension All-Terrain Vehicle Based on LQR
In order to enhance the attitude control ability of all-terrain vehicles in complex terrain, a dual closed-loop control strategy based on LQR controller is designed with series active suspension all-terrain ve...
-
Article
Open AccessCo-targeting BCL-XL and MCL-1 with DT2216 and AZD8055 synergistically inhibit small-cell lung cancer growth without causing on-target toxicities in mice
Small-cell lung cancer (SCLC) is an aggressive malignancy with limited therapeutic options. The dismal prognosis in SCLC is in part associated with an upregulation of BCL-2 family anti-apoptotic proteins, incl...
-
Article
Open AccessmTOR pathway gene expression in association with race and clinicopathological characteristics in Black and White breast cancer patients
Aberrant activation of the mammalian Target of Rapamycin (mTOR) pathway has been linked to obesity and endocrine therapy resistance, factors that may contribute to Black-White disparities in breast cancer outc...
-
Article
Open AccessDevelopment of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity,
PROteolysis-TArgeting Chimeras (PROTACs) have emerged as an innovative drug development platform. However, most PROTACs have been generated empirically because many determinants of PROTAC specificity and activ...
-
Article
Open AccessThe GPR171 pathway suppresses T cell activation and limits antitumor immunity
The recently identified G-protein-coupled receptor GPR171 and its ligand BigLEN are thought to regulate food uptake and anxiety. Though GPR171 is commonly used as a T cell signature gene in transcriptomic stud...
-
Article
Open AccessCD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells
Regulatory T (Treg) cells are one of the major immunosuppressive cell types in cancer and a potential target for immunotherapy, but targeting tumor-infiltrating (TI) Treg cells has been challenging. Here, usin...
-
Article
Open AccessBody fatness and breast cancer risk in relation to phosphorylated mTOR expression in a sample of predominately Black women
The mechanistic target of rapamycin (mTOR) pathway promoted by positive energy imbalance and insulin-like growth factors can be a mechanism by which obesity influences breast cancer risk. We evaluated the asso...
-
Article
Open AccessProteolysis-targeting chimera against BCL-XL destroys tumor-infiltrating regulatory T cells
Regulatory T cells (Tregs) play an important role in maintaining immune homeostasis and, within tumors, their upregulation is common and promotes an immunosuppressive microenvironment. Therapeutic strategies t...
-
Article
Open AccessMap** the immune environment in clear cell renal carcinoma by single-cell genomics
Clear cell renal cell carcinoma (ccRCC) is one of the most immunologically distinct tumor types due to high response rate to immunotherapies, despite low tumor mutational burden. To characterize the tumor immu...
-
Chapter
Understanding and Targeting Human Cancer Regulatory T Cells to Improve Therapy
Regulatory T cells (Tregs) are critical in maintaining immune homeostasis under various pathophysiological conditions. A growing body of evidence demonstrates that Tregs play an important role in cancer progre...
-
Article
Open AccessBody fatness and mTOR pathway activation of breast cancer in the Women’s Circle of Health Study
Energy imbalance has an important role in breast cancer prognosis. Hyperactive mechanistic Target of Rapamycin (mTOR) pathway is associated with breast tumor growth, but the extent to which body fatness is ass...
-
Article
Cancer cell-intrinsic function of CD177 in attenuating β-catenin signaling
Aiming to identify immune molecules with a novel function in cancer pathogenesis, we found the cluster of differentiation 177 (CD177), a known neutrophil antigen, to be positively correlated with relapse-free, me...
-
Chapter
IL-1 Signaling in Tumor Microenvironment
Interleukin 1 (IL-1) has long been known for its pleiotropic effects on inflammation that plays a complex, and sometimes contrasting, role in different stages of cancer development. As a major proinflammatory ...
-
Article
A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity
B-cell lymphoma extra large (BCL-XL) is a well-validated cancer target. However, the on-target and dose-limiting thrombocytopenia limits the use of BCL-XL inhibitors, such as ABT263, as safe and effective antican...
-
Article
Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 4
Obesity is a risk factor for breast cancer and also predicts poor clinical outcomes regardless of menopausal status. Contributing to the poor clinical outcomes is the suboptimal efficacy of standard therapies ...
-
Article
Preparation of electrospun heterostructured hollow SnO2/CuO nanofibers and their enhanced visible light photocatalytic performance
Heterostructured SnO2/CuO nanofibers with a hollow morphology were successfully fabricated by a one-step electrospinning method. The electrospun nanofibers were transformed into hollow nanostructures in the prese...
-
Article
Genetic enhancement in cultured human adult stem cells conferred by a single nucleotide recoding
-
Article
Open AccessVisualization of aging-associated chromatin alterations with an engineered TALE system
Visualization of specific genomic loci in live cells is a prerequisite for the investigation of dynamic changes in chromatin architecture during diverse biological processes, such as cellular aging. However, c...
