Page
%P
-
Article
Open AccessGPR182 limits antitumor immunity via chemokine scavenging in mouse melanoma models
For many solid tumors, immune checkpoint blockade therapy has become first line treatment, yet a large proportion of patients with immunologically cold tumors do not benefit due to the paucity of tumor infiltr...
-
Article
Open AccessThe GPR171 pathway suppresses T cell activation and limits antitumor immunity
The recently identified G-protein-coupled receptor GPR171 and its ligand BigLEN are thought to regulate food uptake and anxiety. Though GPR171 is commonly used as a T cell signature gene in transcriptomic stud...
