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  1. Article

    Open Access

    CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells

    Regulatory T (Treg) cells are one of the major immunosuppressive cell types in cancer and a potential target for immunotherapy, but targeting tumor-infiltrating (TI) Treg cells has been challenging. Here, usin...

    Myung-Chul Kim, Nicholas Borcherding, Kawther K. Ahmed in Nature Communications (2021)

  2. Article

    Open Access

    Map** the immune environment in clear cell renal carcinoma by single-cell genomics

    Clear cell renal cell carcinoma (ccRCC) is one of the most immunologically distinct tumor types due to high response rate to immunotherapies, despite low tumor mutational burden. To characterize the tumor immu...

    Nicholas Borcherding, Ajaykumar Vishwakarma, Andrew P. Voigt in Communications Biology (2021)

  3. No Access

    Article

    Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 4

    Obesity is a risk factor for breast cancer and also predicts poor clinical outcomes regardless of menopausal status. Contributing to the poor clinical outcomes is the suboptimal efficacy of standard therapies ...

    Ryan Kolb, Paige Kluz, Zhen Wei Tan, Nicholas Borcherding, Nicholas Bormann in Oncogene (2019)