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Article
Longitudinal health-related quality of life analysis in childhood cancer survivors after proton beam therapy
Whilst proton beam therapy (PBT) for children with cancer is expected to reduce their comorbidities, to date only a limited number of studies have been published. To analyze the long-term comorbidity and healt...
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Article
Involvement of the optic pathway and outcome of visual function in patients with neurohypophyseal germ cell tumor
Patients with neurohypophyseal germ cell tumors (GCTs) typically present with visual problems. Hence, this study aimed to assess optic pathway involvement based on clinical and radiological findings and to val...
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Article
Open AccessMaximum resection and immunotherapy improve glioblastoma patient survival: a retrospective single-institution prognostic analysis
Glioblastoma (GBM) is a refractory disease with a poor prognosis and various methods, including maximum resection and immunotherapy, have been tested to improve outcomes. In this retrospective study we analyze...
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Article
Association of Kabuki syndrome and tethered cord syndrome: a report of three cases and literature review
Kabuki syndrome (KS) is a congenital disorder characterized by distinctive facial features, skeletal and dermatoglyphic abnormalities, mild-to-moderate intellectual disability, and postnatal growth deficiency....
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Article
Time to diagnosis and clinical characteristics in pediatric brain tumor patients
We aimed to identify factors that affect the time to diagnosis in pediatric brain tumors and investigate the effect of time to diagnosis on clinical outcome.
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Article
Open AccessQuadrigeminal arachnoid cyst with perinatal encephalocele
Quadrigeminal arachnoid cyst (QAC) associated with encephalocele is rare; and while some treatments have been developed in recent years, no definite therapeutic approach for QAC has been established. Endoscopi...
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Article
Proton therapy for newly diagnosed pediatric diffuse intrinsic pontine glioma
Diffuse intrinsic pontine glioma (DIPG) is a type of brain malignancy with a very poor prognosis. Although various radiation and chemotherapy protocols have been attempted, only conventional radiotherapy has y...
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Article
Pure germinoma occurring 11 years after total pineal mature teratoma removal: a case report and review of the literature
Intracranial mature teratomas have good prognoses and are usually treated by total tumor resection. We report a rare case of a germinoma that occurred 11 years after total removal of a pineal mature teratoma. ...
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Article
Primary cavernous sinus germinoma with atypical extension pattern: a case report and review of the literature
Primary intracranial germinoma is a rare central nervous system tumor that usually arises in the pineal and the supra-sellar region. Here, we report a rare case of primary intracavernous sinus germinoma with a...
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Article
A critical role of noggin in develo** folate-nonresponsive NTD in Fkbp8 −/− embryos
Maternal folate intake has reduced the incidence of human neural tube defects by 60–70 %. However, 30–40 % of cases remain nonresponsive to folate intake. The main purpose of this study was to understand the m...
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Article
Epigenetic modification after inhibition of IGF-1R signaling in human central nervous system atypical teratoid rhabdoid tumor (AT/RT)
This study investigated epigenetic modifications in human central nervous system atypical teratoid rhabdoid tumors (AT/RTs), in response to inhibition of insulin-like growth factor receptor 1 (IGF-1R).
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Article
Open AccessNuclear localization of folate receptor alpha: a new role as a transcription factor
Folic acid (FA) has traditionally been associated with prevention of neural tube defects; more recent work suggests that it may also be involved in in the prevention of adult onset diseases. As the role of FA ...
