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Open AccessErratum: GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium
Correction to: Molecular Psychiatry (2017) 22, 336–345; doi:10.1038/mp.2016.244;published online 17 January 2017 Data access for several cohorts used in this study was provided by the National Center for Biote...
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Open AccessGWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium
The complex nature of human cognition has resulted in cognitive genomics lagging behind many other fields in terms of gene discovery using genome-wide association study (GWAS) methods. In an attempt to overcom...
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Paternal age, de novo mutations and schizophrenia
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GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia
We conducted data-mining analyses using the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) and molecular genetics of schizophrenia genome-wide association study supported by the genetic as...
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A 5′ promoter region SNP in NRG1 is associated with schizophrenia risk and type III isoform expression
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Serious obstetric complications interact with hypoxia-regulated/vascular-expression genes to influence schizophrenia risk
The etiology of schizophrenia is thought to include both epistasis and gene-environment interactions. We sought to test whether a set of schizophrenia candidate genes regulated by hypoxia or involved in vascul...
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Imaging epistasis in vivo: COMT and RGS4
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fMRI evidence for functional epistasis between COMT and RGS4
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Significant correlation in linkage signals from genome-wide scans of schizophrenia and schizotypy
Prior family and adoption studies have suggested a genetic relationship between schizophrenia and schizotypy. However, this has never been verified using linkage methods. We therefore attempted to test for a c...
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Erratum: Further evidence for association between ErbB4 and schizophrenia and influence on cognitive intermediate phenotypes in healthy controls
Correction to: Molecular Psychiatry (2006) 11, 1062–1065; doi:10.1038/sj.mp.4001878 Following publication of the above article, the authors noted that two copies of Table 1 (an incomplete version on page 1063 ...
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Allelic variation in GAD1 (GAD67) is associated with schizophrenia and influences cortical function and gene expression
Cortical GABAergic dysfunction has been implicated as a key component of the pathophysiology of schizophrenia and decreased expression of the gamma-aminobutyric acid (GABA) synthetic enzyme glutamic acid decar...
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Further evidence for association between ErbB4 and schizophrenia and influence on cognitive intermediate phenotypes in healthy controls
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Dysbindin (DTNBP1, 6p22.3) is Associated with Childhood-Onset Psychosis and Endophenotypes Measured by the Premorbid Adjustment Scale (PAS)
Straub et al. (2002) recently identified the 6p22.3 gene dysbindin (DTNBP1) through positional cloning as a schizophrenia susceptibility gene. We studied a rare cohort of 102 children with onset of psychosis befo...
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GAD1 (2q31.1), which encodes glutamic acid decarboxylase (GAD67), is associated with childhood-onset schizophrenia and cortical gray matter volume loss
Postmortem brain studies have shown deficits in the cortical γ-aminobutyric acid (GABA) system in schizophrenic individuals. Expression studies have shown a decrease in the major GABA-synthesizing enzyme (glutami...
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Expression analysis of neuregulin-1 in the dorsolateral prefrontal cortex in schizophrenia
Genetic linkage and association have implicated neuregulin-1 (NRG-1) as a schizophrenia susceptibility gene. We measured mRNA expression levels of the three major isoforms of NRG-1 (ie type I, type II, and typ...
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Genome-wide scans of three independent sets of 90 Irish multiplex schizophrenia families and follow-up of selected regions in all families provides evidence for multiple susceptibility genes
From our linkage study of Irish families with a high density of schizophrenia, we have previously reported evidence for susceptibility genes in regions 5q21–31, 6p24–21, 8p22–21, and 10p15–p11. In this report,...
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No evidence to support the association of the potassium channel gene hSKCa3 CAG repeat with schizophrenia or bipolar disorder in the Irish population
Anticipation has attracted much interest and has been demonstrated in several neuropsychiatric disorders. For some disorders, this phenomenon has been found to correlate with the repeat number in large and uns...
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Susceptibility genes for nicotine dependence: a genome scan and followup in an independent sample suggest that regions on chromosomes 2, 4, 10, 16, 17 and 18 merit further study
Cigarette smoking is associated with considerable morbidity, mortality, and public health costs. Genetic factors influence both smoking initiation and nicotine dependence, but none of the genes involved have b...
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Examination of new and reported data of the DRD3/MscI polymorphism: no support for the proposed association with schizophrenia
The dopamine D3 (DRD3) receptor gene has been implicated in the aetiology of schizophrenia as a candidate gene since it combines both the dopamine receptor and limbic hypotheses of the disease. Previous associ...
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Support for a possible schizophrenia vulnerability locus in region 5q22–31 in Irish families
In our genome scan for schizophrenia genes in 265 Irish pedigrees, marker D5S818 in 5q22 produced the second best result of the first 223 markers tested (P = 0.002). We then tested an additional 13 markers and th...