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  1. No Access

    Article

    Contrasting changes in DRD1 and DRD2 splice variant expression in schizophrenia and affective disorders, and associations with SNPs in postmortem brain

    Dopamine 2 receptor (DRD2) is of major interest to the pathophysiology of schizophrenia (SCZ) both as a target for antipsychotic drug action as well as a SCZ-associated risk gene. The dopamine 1 receptor (DRD1...

    S S Kaalund, E N Newburn, T Ye, R Tao, C Li, A Deep-Soboslay… in Molecular Psychiatry (2014)

  2. No Access

    Article

    RNA-sequencing of the brain transcriptome implicates dysregulation of neuroplasticity, circadian rhythms and GTPase binding in bipolar disorder

    RNA-sequencing (RNA-seq) is a powerful technique to investigate the complexity of gene expression in the human brain. We used RNA-seq to survey the brain transcriptome in high-quality postmortem dorsolateral p...

    N Akula, J Barb, X Jiang, J R Wendland, K H Choi, S K Sen, L Hou… in Molecular Psychiatry (2014)

  3. No Access

    Article

    Revisiting DARPP-32 in postmortem human brain: changes in schizophrenia and bipolar disorder and genetic associations with t-DARPP-32 expression

    Dopamine- and cAMP-regulated phosphoprotein of molecular weight 32 kDa (DARPP-32 or PPP1R1B) has been of interest in schizophrenia owing to its critical function in integrating dopaminergic and glutaminergic sign...

    Y Kunii, T M Hyde, T Ye, C Li, B Kolachana, D Dickinson… in Molecular Psychiatry (2014)

  4. Article

    Open Access

    Interactions of human truncated DISC1 proteins: implications for schizophrenia

    Numerous genetic linkage and association reports have implicated the Disrupted-in-Schizophrenia (DISC1) gene in psychiatric illness. The Scottish family translocation, predicted to encode a C-terminus-truncated p...

    E N Newburn, T M Hyde, T Ye, Y Morita, D R Weinberger… in Translational Psychiatry (2011)

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  5. No Access

    Article

    Evidence that many of the DISC1 isoforms in C57BL/6J mice are also expressed in 129S6/SvEv mice

    K Ishizuka, J Chen, S Taya, W Li, J K Millar, Y Xu, S J Clapcote… in Molecular Psychiatry (2007)

  6. No Access

    Article

    Allelic variation in GAD1 (GAD67) is associated with schizophrenia and influences cortical function and gene expression

    Cortical GABAergic dysfunction has been implicated as a key component of the pathophysiology of schizophrenia and decreased expression of the gamma-aminobutyric acid (GABA) synthetic enzyme glutamic acid decar...

    R E Straub, B K Lipska, M F Egan, T E Goldberg, J H Callicott… in Molecular Psychiatry (2007)

  7. No Access

    Article

    Presynaptic proteins in the prefrontal cortex of patients with schizophrenia and rats with abnormal prefrontal development

    Dysfunction of the prefrontal cortex in schizophrenia may be associated with abnormalities in synaptic structure and/or function and reflected in altered concentrations of proteins in presynaptic terminals and...

    N D Halim, C S Weickert, B W McClintock, T M Hyde, D R Weinberger… in Molecular Psychiatry (2003)

  8. No Access

    Article

    Reduced brain-derived neurotrophic factor in prefrontal cortex of patients with schizophrenia

    Anatomical and molecular abnormalities of excitatory neurons in the dorsolateral prefrontal cortex (DLPFC) are found in schizophrenia. We hypothesized that brain-derived neurotrophic factor (BDNF), a protein c...

    C S Weickert, T M Hyde, B K Lipska, M M Herman, D R Weinberger… in Molecular Psychiatry (2003)

  9. No Access

    Article

    Developmental and stress-related changes of neurotrophic factor gene expression in an animal model of schizophrenia

    The neonatal (PND 7) lesion of the ventral hippocampus (VH) with ibotenic acid represents a well-established experimental paradigm that recapitulates many schizophrenia-like phenomena. In order to investigate ...

    R Molteni, B K Lipska, D R Weinberger, G Racagni, M A Riva in Molecular Psychiatry (2001)

  10. No Access

    Article

    Attenuated extracellular dopamine levels after stress and amphetamine in the nucleus accumbens of rats with neonatal ventral hippocampal damage

    In vivo microdialysis was used to study the effects of restraint stress (30 min) and amphetamine (AMPH) (5 mg/kg, i.p.) in awake adult male rats with neonatal ventral hippocampal (VH) damage. Extracellular le...

    S. M. Lillrank, B. K. Lipska, B. S. Kolachana… in Journal of Neural Transmission (1999)

  11. No Access

    Article

    Effects of chronic neuroleptic treatment on dopamine release: Insights from studies using 3-methoxytyramine

    Antipsychotic medications appear to exert their therapeutic effects by blocking D2 receptors. While D2 blockade occurs rapidly, reduction in psychotic symptoms is often delayed. This time discrepancy has been ...

    M. F. Egan, S. Chrapusta, F. Karoum, B. K. Lipska… in Journal of Neural Transmission (1996)

  12. No Access

    Article

    Increased sensitivity to the sensorimotor gating-disruptive effects of apomorphine after lesions of medial prefrontal cortex or ventral hippocampus in adult rats

    Sensorimotor gating of the startle reflex is impaired in humans with schizophrenia and in rats after mesolimbic D2 dopamine receptor activation. The loss of startle gating after D2 activation in rats has been use...

    N. R. Swerdlow, D. L. Braff, M. A. Geyer, B. K. Lipska… in Psychopharmacology (1995)

  13. No Access

    Article

    Neonatal excitotoxic hippocampal damage in rats causes post-pubertal changes in prepulse inhibition of startle and its disruption by apomorphine

    Neonatal excitotoxic hippocampal damage in the rat results in postpubertal onset of a variety of abnormal behaviors related to excessive dopaminergic transmission in the mesolimbic/nigrostriatal system, and th...

    B. K. Lipska, D. R. Weinberger, N. R. Swerdlow, M. A. Geyer… in Psychopharmacology (1995)