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Article
Assessment of myopic rebound effect after discontinuation of treatment with 0.01% atropine eye drops in Japanese school-age children
Having previously demonstrated the efficacy of 0.01% atropine eye drops for inhibiting progression of childhood myopia, we conducted additional analyses to assess post-treatment changes in myopia progression.
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Article
Open AccessDifferences in gene regulation by TLR3 and IPS-1 signaling in murine corneal epithelial cells
Toll-like receptor 3 (TLR3) and interferon-beta promoter stimulator-1 (IPS-1) are associated with antiviral responses to double-stranded RNA viruses and contribute to innate immunity. We previously reported th...
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Corneal Endothelial Cell Transfer
Today, different concepts of regenerative-medicine cell-based therapy are applied for the treatment of damaged tissue. Of those, one is the release of beneficial small molecules via the transfer of cultured ce...
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Article
Open AccessQuiescent innate and adaptive immune responses maintain the long-term integrity of corneal endothelium reconstituted through allogeneic cell injection therapy
This study aims to clarify the immunogenicity in acquired and innate immune responses of cultured human corneal endothelial cells (hCECs) applied for cell injection therapy, a newly established modality for co...
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Article
Temperature effects on the disappearance and reappearance of corneal-endothelium primary cilia
To elucidate the specific functions of the primary cilia in corneal endothelial cells (CECs) by investigating the histological changes of corneal endothelium exposed at low temperature.
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Article
Risk factors for intraocular pressure elevation during the early period post cataract surgery
To assess the risk factors for intraocular pressure (IOP) elevation during the early period post cataract surgery.
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Article
Potential participation of CTRP6, a complement regulator, in the pathology of age related macular degeneration
To investigate the localized expression of C1q/tumor necrosis factor related protein (CTRP) 6 in human age-related macular degeneration (AMD) retinal tissues.
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Article
Open AccessIntracellular pH affects mitochondrial homeostasis in cultured human corneal endothelial cells prepared for cell injection therapy
This study aimed to uncover the mechanism responsible for the clinical efficacy of cell injection therapy with fully differentiated cultured cells. Analysis of polarized expression of ion transporters on cultu...
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Article
Open AccessIntracrine activity involving NAD-dependent circadian steroidogenic activity governs age-associated meibomian gland dysfunction
Canonically, hormones are produced in the endocrine organs and delivered to target tissues. However, for steroids, the concept of tissue intracrinology, whereby hormones are produced in the tissues where they ...
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Article
A multicenter clinical trial of orthokeratology in school-aged children and adolescents in Japan
This study investigated the safety and efficacy of orthokeratology in myopic children in Japan.
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Article
Comparison of myopia progression between children wearing three types of orthokeratology lenses and children wearing single-vision spectacles
To evaluate factors related to myopia progression in children wearing either orthokeratology (OK) lenses or single-vision spectacles (SVS) for 2 years.
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Article
Open AccessSurgical outcomes of re-excimer laser phototherapeutic keratectomy (re-PTK)
To assess the surgical outcomes of re-excimer laser phototherapeutic keratectomy (re-PTK) for recurrent disease after initial PTK. Retrospective cohort study with historical comparison group. This study involv...
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Article
Efficacy and safety of 0.01% atropine for prevention of childhood myopia in a 2-year randomized placebo-controlled study
Atropine eye drops prevent the progression of myopia, but their use has not been tested in the Japanese schoolchildren population. Here, we evaluate the efficacy and safety of 0.01% atropine eye drops for myop...
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Article
Outcomes of combined gonioscopy-assisted transluminal trabeculotomy and goniosynechialysis in primary angle closure: a retrospective case series
To evaluate the additional intraocular pressure (IOP) lowering effect of gonioscopy-assisted transluminal trabeculotomy (GATT) to contemporary goniosynechialysis (GSL) in endeavouring to abolish subsequent occ...
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Article
Open AccessComparison of penetrating keratoplasty outcomes with or without microwave thermokeratoplasty
Microwave thermokeratoplasty (MTK) is a surgical procedure for the correction of pathologic corneal steepening. The purpose of this study was to examine the postoperative outcomes of eyes with advanced keratoc...
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Article
Open AccessMap** of susceptible variants for cold medicine-related Stevens–Johnson syndrome by whole-genome resequencing
Stevens–Johnson syndrome (SJS) and its severe condition with extensive skin detachment and a poor prognosis, toxic epidermal necrolysis (TEN), are immunologically mediated severe cutaneous reactions of the ski...
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Article
Open AccessHuman leukocyte antigen B*0702 is protective against ocular Stevens–Johnson syndrome/toxic epidermal necrolysis in the UK population
Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis (SJS/TEN) are part of a disease continuum of vesiculobullous mucocutaneous reactions affecting the skin and mucous membranes including the ocular surface...
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Article
Pterygium excision with modified bare sclera technique combined with mitomycin C
Numerous surgical methods, with varying rates of recurrence, have been applied for the treatment of pterygium. Adjuvant mitomycin C (MMC) application has shown promising results in the prevention of recurrence...
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Article
Open AccessNovel use of a chemically modified siRNA for robust and sustainable in vivo gene silencing in the retina
Despite efficient and specific in vitro knockdown, more reliable and convenient methods for in vivo knockdown of target genes remain to be developed particularly for retinal research. Using commercially availa...
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Article
Incidence and Management of Cystoid Macular Edema after Corneal Transplantation
In this review, we overview the incidence and management of cystoid macular edema following endothelial keratoplasty (EK) including Descemet’s strip** automated endothelial keratoplasty (DSAEK) and Descemet’...
